Roles of B-1 and B-2 cells in innate and acquired IgA-mediated immunity

被引：54

作者：

Suzuki, Keiichiro ^{[1
]}

Maruya, Mikako ^{[1
]}

Kawamoto, Shimpei ^{[1
,2
]}

Fagarasan, Sidonia ^{[1
]}

机构：

[1] RIKEN Res Ctr Allergy & Immunol, Lab Mucosal Immun, Yokohama, Kanagawa 2300045, Japan

[2] Kyoto Univ, Sch Med, Dept Immunol & Genom Med, Sakyo Ku, Kyoto 606, Japan

来源：

IMMUNOLOGICAL REVIEWS | 2010年 / 237卷

关键词：

AID; bacteria; B-1; cells; IgA; T-independent; T-dependent; ISOLATED LYMPHOID FOLLICLES; INDUCED CYTIDINE DEAMINASE; TISSUE-INDUCER CELLS; SEGMENTED FILAMENTOUS BACTERIA; INTESTINAL DENDRITIC CELLS; GUT LAMINA PROPRIA; HELPER T-CELLS; LY-1; B-CELLS; RETINOIC-ACID; BETA-RECEPTOR;

D O I：

10.1111/j.1600-065X.2010.00941.x

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

The gut harbors an extremely dense and complex community of microorganisms that are in constant dialog with our immune cells. The gut bacteria provide strong selective pressure to the host to evolve innate and adaptive immune responses required for the maintenance of local and systemic homeostasis. One of the most conspicuous responses of the gut immune system following microbial colonization is the production of immunoglobulin A (IgA). In this review, we discuss the roles of B-1 and B-2 cells in IgA-mediated immunity and present an updated view for the sites and mechanisms of IgA synthesis in the gut. We summarize the role of secretory IgAs for regulation of microbial communities and provide clues as to how the gut microbiota contributes to the development of the gut-associated lymphoid tissues.

引用

页码：180 / 190

页数：11

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