Evidence for a genetic predisposition for status epilepticus

被引：42

作者：

Corey, LA

Pellock, JM

Boggs, JG

Miller, LL

DeLorenzo, RJ

机构：

[1] Virginia Commonwealth Univ, Virginia Inst Psychiat & Behav Genet, Dept Human Genet, Med Coll Virginia, Richmond, VA 23298 USA

[2] Virginia Commonwealth Univ, Med Coll Virginia, Dept Neurol, Richmond, VA 23298 USA

[3] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pediat, Richmond, VA 23298 USA

[4] Virginia Commonwealth Univ, Med Coll Virginia, Dept Biochem & Mol Biophys, Richmond, VA 23298 USA

[5] Virginia Commonwealth Univ, Med Coll Virginia, Dept Pharmacol & Toxicol, Richmond, VA 23298 USA

[6] Virginia Commonwealth Univ, Med Coll Virginia, Comprehens Epilepsy Inst, Richmond, VA 23298 USA

来源：

NEUROLOGY | 1998年 / 50卷 / 02期

关键词：

D O I：

10.1212/WNL.50.2.558

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The role of genetic factors in determining risk for status epilepticus (SE) was examined in twins identified using the population-based Virginia Twin Registry. Concordance rates for SE were 0.38 for monozygotic (MZ) and 0.00 for dizygotic (DZ) twins, with the rate in MZs being significantly increased over DZs. The prevalence of SE in MZ co-twins of affected individuals was as high as 0.55. Clinical presentation of SE was evaluated, and no association was found between occurrence of SE and age at onset or seizure etiology. Genetic factors contribute to risk for SE.

引用

页码：558 / 560

页数：3

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