Serum concentration of hepatocyte growth factor in patients with metastatic breast cancer

被引：44

作者：

Maemura, M

Lino, Y

Yokoe, T

Horiguchi, J

Takei, H

Koibuchi, Y

Horii, Y

Takeyoshi, I

Ohwada, S

Morishita, Y

机构：

[1] Gunma Univ, Sch Med, Dept Surg 2, Maebashi, Gumma 371, Japan

[2] Gunma Univ, Sch Med, Dept Emergency & Crit Care Med, Maebashi, Gumma 371, Japan

来源：

CANCER LETTERS | 1998年 / 126卷 / 02期

关键词：

breast cancer; hepatocyte growth factor; metastasis; malignant progression;

D O I：

10.1016/S0304-3835(98)00014-7

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The serum concentration of hepatocyte growth factor (HGF) was examined in 34 patients with metastatic breast cancer. Although no significant difference was observed between HGF concentration and the site of metastasis, serum HGF levels were slightly higher in patients with liver metastasis and in patients with multiple metastatic sites than in patients with other lesions. Significantly higher levels of serum HGF were observed in patients with progressive metastasis of breast cancer compared with those with stable metastasis. The patients with high HGF levels exhibited a significantly shorter survival rate than those with low HGF levels. Circulating HGF levels may be a useful indicator for the progression of metastatic lesions and the prognosis of patients with metastatic breast cancer. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：215 / 220

页数：6

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