Therapeutic effects of 5-fluorouracil microspheres on peritoneal carcinomatosis induced by Colon 26 or B-16 melanoma in mice

被引：11

作者：

Hagiwara, A

Sakakura, C

Shirasu, M

Yamasaki, J

Togawa, T

Takahashi, T

Muranishi, S

Hyon, S

Ikada, Y

机构：

[1] Kyoto Prefectural Univ Med, Dept Surg 1, Kamigyo Ku, Kyoto 602, Japan

[2] Kyoto Univ, Res Ctr Med Polymers, Sakyo Ku, Kyoto 602, Japan

[3] Kyoto Univ, Coll Pharm, Dept Biopharmaceut, Kyoto, Japan

来源：

ANTI-CANCER DRUGS | 1998年 / 9卷 / 03期

关键词：

5-fluorouracil; animal experiments; intraperitoneal chemotherapy; microspheres; peritoneal; carcinomatosis;

D O I：

10.1097/00001813-199803000-00012

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The delivery formulation 5-FU-MS [5-fluorouracil (5-FU) incorporated in microspheres composed of a poly(glycolide-co-lactide) matrix] slowly releases 5-FU over 3 weeks. 5-FU-MS delivers higher concentrations of the drug to the i.p. tissues for a longer period of time with lower blood plasma concentrations than does an aqueous 5-FU solution and reduces toxicity. In this study, we evaluated the therapeutic effects of 5-FU-MS on peritoneal carcinomatosis in mice. Four days after an i.p. inoculation with Colon 26 or B-16 PC melanoma, 5-FU at 200 mg/kg was administered i.p. as 5-FU-MS or as an aqueous solution of 5-FU. 5-FU-MS extended the survival of mice bearing Colon 26 or B-16 PC melanoma significantly better than the equivalent dose of aqueous 5-FU solution. [(C) 1998 Rapid Science Ltd.].

引用

页码：287 / 289

页数：3