Pharmacokinetics of azithromycin in trachoma patients - Serum and tear levels

被引:10
作者
Karcioglu, ZA
El-Yazigi, A
Jabak, MH
Choudhury, AH
Ahmed, WS
机构
[1] King Khalid Eye Specialist Hosp, Med Lib, Riyadh 11462, Saudi Arabia
[2] King Faisal Specialist Hosp & Res Ctr, Riyadh 11211, Saudi Arabia
[3] Trachoma Control Program, Al Ahssa, Saudi Arabia
关键词
D O I
10.1016/S0161-6420(98)94020-9
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Objective: To determine the effectiveness of single-dose oral azithromycin in the treatment of Chlamydia trachomatis through monitoring of tear and serum levels. Design: Nonrandomized, clinical trial. Participants: Fourteen school-age children with active trachoma (one failed to complete the study). Intervention: A single dose of azithromycin (20 mg/kg) was administered orally to 14 patients, and tear and serum levels were determined with high-performance liquid chromatography at 12, 24, 48, 72, 96, 120, and 144 hours after administration. Main Outcome Measures: Azithromycin levels in tears and serum. Results: Peak levels of 1.53 mu g/ml (standard deviation [SD] +/- 0.94) and 0.15 mu g/ml (SD +/- 0.04) were obtained al 12 hours in both tears and serum, gradually decreasing over 144 hours. All patients were disease-free by 6 months. Conclusions: Levels of azithromycin in patients with trachoma were found to be within minimum inhibitory concentration range for Chlamydia trachomatis (0.03-0.25 mu g/ml) throughout the monitored period of 6 days.
引用
收藏
页码:658 / 661
页数:4
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