Growth and aging: a common molecular mechanism

被引：178

作者：

Blagosklonny, Mikhail V. ^{[1
]}

Hall, Michael N. ^{[2
]}

机构：

[1] Roswell Pk Canc Inst, Buffalo, NY 14263 USA

[2] Univ Basel, Biozentrum, CH-4056 Basel, Switzerland

来源：

AGING-US | 2009年 / 1卷 / 04期

基金：

瑞士国家科学基金会;

关键词：

aging; growth; rapamycin; TOR; mitochondria; LIFE-SPAN EXTENSION; CALORIE RESTRICTION; CELLULAR SENESCENCE; INSULIN-RECEPTOR; SACCHAROMYCES-CEREVISIAE; REDUCED INCIDENCE; MAMMALIAN TARGET; UP-REGULATION; TOR; YEAST;

D O I：

10.18632/aging.100040

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

It is commonly assumed that growth and aging are somehow linked, but the nature of this link has been elusive. Here we review the aging process as a continuation of TOR-driven growth. TOR is absolutely essential for developmental growth, but upon completion of development it causes aging and age-related diseases. Thus, the nutrient-sensing and growth-promoting TOR signaling pathway may provide a molecular link between growth and aging that is universal from yeast to human.

引用

收藏

页码：357 / 362

页数：6

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