Helicobacter pylori infection and insulin-dependent diabetes mellitus

被引:63
作者
de Luis, DA [1 ]
de la Calle, H
Roy, G
de Argila, CM
Valdezate, S
Canton, R
Boixeda, D
机构
[1] Univ Alcala de Henares, Ha Ramon & Cajal, Dept Endocrinol, Madrid 28034, Spain
[2] Univ Alcala de Henares, Ha Ramon & Cajal, Dept Immunol, Madrid 28034, Spain
[3] Univ Alcala de Henares, Ha Ramon & Cajal, Dept Gastroenterol, Madrid 28034, Spain
[4] Univ Alcala de Henares, Ha Ramon & Cajal, Dept Microbiol, Madrid 28034, Spain
关键词
Helicobacter pylori seroprevalence; diabetes mellitus; pathogenesis;
D O I
10.1016/S0168-8227(97)00127-7
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Helicobacter pylori is associated with different diseases: duodenal ulcer, rosacea, ischaemic heart disease and gastric cancer. Given the abnormal immunological response and the high prevalence of gastrointestinal symptoms in diabetic patients, we conducted a study on H. pylori prevalence among these patients. We designed a case control study of a population-based cohort. Eighty insulin-dependent diabetes mellitus (IDDM) patients with an average age (24.05+/-8.3 years), and 100 control subjects (25+/-7.1 years) were selected to verify the seroprevalence of Helicobacter pylori in these populations. One serum sample was obtained from each subject for evaluation of antibodies against Helicobacter pylori, parietal cells (APA) and pancreatic islets cells (ICA). The seroprevalence of H. pylori among IDDM patients aged less than 24 years was significantly higher than among control subjects; the corresponding rate among IDDM aged greater than 24 years was significantly lower than among control subjects. Antibodies against parietal cells (APA) and islet cells (ICA) among H. pylori positive diabetic patients were significantly higher than among H. pylori negative diabetic patients. IDDM patients were subdivided on the basis of the evolutive course of diabetes. Seroprevalence of H. pylori as well as prevalence of ICAs decreased with IDDM duration. Nevertheless, Ilo variation in the prevalence of APAs during the course of diabetes was observed. We observed an association between the seroprevalence of Helicobacter pylori and the duration of IDDM. The seroprevalence of H. pylori and ICA decreased with the evolutive course of diabetes mellitus among IDDM. The prevalence of ICA and APA in IDDM H. pylori positive subjects was higher than among controls. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.
引用
收藏
页码:143 / 146
页数:4
相关论文
共 19 条
[1]   INTRAFAMILIAL CLUSTERING OF HELICOBACTER-PYLORI INFECTION [J].
DRUMM, B ;
PEREZPEREZ, GI ;
BLASER, MJ ;
SHERMAN, PM .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (06) :359-363
[2]   DISORDERS OF GASTROINTESTINAL MOTILITY ASSOCIATED WITH DIABETES-MELLITUS [J].
FELDMAN, M ;
SCHILLER, LR .
ANNALS OF INTERNAL MEDICINE, 1983, 98 (03) :378-384
[3]  
FENG YY, 1988, LANCET, V1, P1055
[4]   IMPAIRMENT OF MONOCYTE LECTIN-LIKE RECEPTOR ACTIVITY IN TYPE-1 (INSULIN-DEPENDENT) DIABETIC-PATIENTS [J].
GLASS, EJ ;
STEWART, J ;
MATTHEWS, DM ;
COLLIER, A ;
CLARKE, BF ;
WEIR, DM .
DIABETOLOGIA, 1987, 30 (04) :228-231
[5]   SEROEPIDEMIOLOGY OF HELICOBACTER-PYLORI INFECTION IN INDIA - COMPARISON OF DEVELOPING AND DEVELOPED-COUNTRIES [J].
GRAHAM, DY ;
ADAM, E ;
REDDY, GT ;
AGARWAL, JP ;
AGARWAL, R ;
EVANS, DJ ;
MALATY, HM ;
EVANS, DG .
DIGESTIVE DISEASES AND SCIENCES, 1991, 36 (08) :1084-1088
[6]   EVIDENCE THAT THE REDUCED NUMBER OF NATURAL-KILLER CELLS IN TYPE-1 (INSULIN-DEPENDENT) DIABETES MAY BE GENETICALLY-DETERMINED [J].
HUSSAIN, MJ ;
ALVIGGI, L ;
MILLWARD, BA ;
LESLIE, RDG ;
PYKE, DA ;
VERGANI, D .
DIABETOLOGIA, 1987, 30 (12) :907-911
[7]  
KATZ LA, 1996, N ENGL MED, V275, P1350
[8]  
Kojecky V, 1993, Vnitr Lek, V39, P581
[9]   HIGH SEROPREVALENCE OF HELICOBACTER-PYLORI INFECTION IN CORONARY HEART-DISEASE [J].
MARTINDEARGILA, C ;
BOIXEDA, D ;
CANTON, R ;
GISBERT, JP ;
FUERTES, A .
LANCET, 1995, 346 (8970) :310-310
[10]   IN-VITRO PRODUCTION OF INTERLEUKIN-1, INTERLEUKIN-6, AND TUMOR-NECROSIS-FACTOR-ALPHA IN INSULIN-DEPENDENT DIABETES-MELLITUS [J].
OHNO, Y ;
AOKI, N ;
NISHIMURA, A .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1993, 77 (04) :1072-1077