Melatonin treatment of winter depression: a pilot study

被引：72

作者：

Lewy, AJ ^{[1
]}

Bauer, VK

Cutler, NL

Sack, RL

机构：

[1] Oregon Hlth & Sci Univ, Dept Psychiat, Sleep & Mood Disorders Lab, Portland, OR 97201 USA

[2] Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR 97201 USA

[3] Oregon Hlth & Sci Univ, Dept Physiol Pharmacol, Portland, OR 97201 USA

来源：

PSYCHIATRY RESEARCH | 1998年 / 77卷 / 01期

关键词：

melatonin; winter depression; seasonal affective disorder; melatonin phase response curve; phase shift hypothesis;

D O I：

10.1016/S0165-1781(97)00128-5

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Five patients with winter depression received low doses of melatonin in the afternoon, and five patients received placebo capsules. Melatonin treatment significantly decreased depression ratings compared to placebo. If these findings are replicated in a larger sample with documentation of expected phase shifts, the phase shift hypothesis will be substantially supported. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：57 / 61

页数：5

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