Kryptonite Bone Cement Prevents Pathologic Sternal Displacement

被引:64
作者
Fedak, Paul W. M.
Kolb, Eric
Borsato, Garry
Frohlich, Dean E. C.
Kasatkin, Aleksey
Narine, Kishan
Akkarapaka, Naresh
King, Kathryn M.
机构
[1] Univ Calgary, Dept Diagnost Imaging, Div Cardiac Surg, Dept Cardiac Sci,Libin Cardiovasc Inst Alberta, Calgary, AB, Canada
[2] Univ Calgary, Fac Nursing, Calgary, AB, Canada
[3] Univ Calgary, Dept Community Hlth Sci, Calgary, AB, Canada
[4] Doctors Res Grp Inc, Dept Bioengn, Southbury, CT USA
关键词
HIGH-RISK PATIENTS; MEDIAN STERNOTOMY; MIDLINE STERNOTOMY; CLOSURE; REINFORCEMENT; DEHISCENCE; INFECTION; STABILITY;
D O I
10.1016/j.athoracsur.2010.05.009
中图分类号
R5 [内科学];
学科分类号
100201 [内科学];
摘要
Background. Wire cerclage closure of sternotomy is the standard of care despite evidence of pathologic sternal displacement (>2 mm) during physiologic distracting forces (coughing). Postoperative functional recovery, respiration, pain, sternal dehiscence, and infection are influenced by early bone stability. This translational research report provides proof-of-concept (part A) and first-in-man clinical data (part B) with use of a triglyceride-based porous adhesive to rapidly enhance the stability of conventional sternal closure. Methods. In part A, fresh human cadaver blocks were subjected to midline sternotomy and either conventional wire closure or modified adhesive closure. After 24 hours at 37 degrees C, using a biomechanical test apparatus, a step-wise increase in lateral distracting force simulated physiologic stress. Sternal displacement was measured by microdisplacement sensors. In part B, a selected clinical case series was performed and sternal perfusion assessed by serial single photon emission computed tomography imaging. Results. Wire closure resulted in measurable bony displacement with increasing load. Pathologic displacement (>= 2 mm) was observed in all regional segments at loads 400 newton (N) or greater. In contrast, adhesive closure completely eliminated pathologic displacement at forces 600 N or less (p < 0.001). In patients, adhesive closure was not associated with adverse events such as adhesive migration, embolization, or infection. There was excellent qualitative correlation between cadaver and clinical computed tomographic images. Sternal perfusion was not compromised by adhesive closure. Conclusions. This first-in-man series provides proof-of-concept indicating that a novel biologic bone adhesive is capable of rapid sternal fixation and complete elimination of pathologic sternal displacement under physiologic loading conditions. A randomized clinical trial is warranted to further define the potential risks and benefits of this innovative technique. (Ann Thorac Surg 2010; 90: 979-85) (C) 2010 by The Society of Thoracic Surgeons
引用
收藏
页码:979 / 985
页数:7
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