Opposite Role of Pro-Inflammatory Alleles in Acute Myocardial Infarction and Longevity Results of Studies Performed in a Sicilian Population

被引：25

作者：

Candore, Giuseppina ^{[1
]}

Balistreri, Carmela Rita ^{[1
]}

Grimaldi, Maria Paola ^{[1
]}

Listi, Florinda ^{[1
]}

Vasto, Sonya ^{[1
]}

Caruso, Marco ^{[2
]}

Caimi, Gregorio ^{[2
]}

Hoffmann, Enrico ^{[2
]}

Colonna-Romano, Giuseppina ^{[1
]}

Lio, Domenico ^{[1
]}

Paolisso, Giuseppe ^{[3
]}

Franceschi, Claudio ^{[4
,5
,6
]}

Caruso, Calogero ^{[1
]}

机构：

[1] Univ Palermo, Dipartimento Biopatol & Metodol Biomed, Grp Studio Immunosenescenza, I-90134 Palermo, Italy

[2] Univ Palermo, Dipartimento Med Interna Malattie Cardiovasc & Ne, I-90134 Palermo, Italy

[3] Univ Naples 2, Dipartimento Med Geriatria & Malattie Metabol, Naples, Italy

[4] Univ Bologna, Dipartimento Patol Sperimentale, I-40126 Bologna, Italy

[5] Univ Bologna, Ctr Interdipartimentale L Galvani, Bologna, Italy

[6] Ist Nazl Riposa & Cura Anziani, Ancona, Italy

来源：

UNDERSTANDING AND MODULATING AGING | 2006年 / 1067卷

关键词：

AMI; CCR5; inflammation; longevity; pyrin;

D O I：

10.1196/annals.1354.035

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

The major trait characterizing offspring in centenarians is a reduction in the prevalence of cardiovascular disease. Because a pro-inflammatory genotype seems to contribute significantly to the risk of coronary heart disease, alleles associated with disease susceptibility would not be included in the genetic background favoring longevity, as suggested by our previous studies on inflammatory cytokines. To confirm whether genotypes of inflammatory molecules play an opposite role in atherosclerosis and longevity, we are studying the role of other proinflammatory alleles, such as pyrin and CCR5, in acute myocardial infarction and longevity. The results support the hypothesis that the genetic background favoring cardiovascular diseases is detrimental to longevity. In addition, they suggest that the centenarian genetic background may be useful for investigating genetic key components of age-associated diseases that are characterized by a multifactorial etiology.

引用

页码：270 / 275

页数：6

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