Armadillo/β-catenin signals in the nucleus -: proof beyond a reasonable doubt?

被引：123

作者：

Bienz, M

Clevers, H

机构：

[1] MRC, Mol Biol Lab, Cambridge CB2 2QH, England

[2] Netherlands Inst Dev Biol, NL-3584 CT Utrecht, Netherlands

来源：

NATURE CELL BIOLOGY | 2003年 / 5卷 / 03期

关键词：

D O I：

10.1038/ncb0303-179

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Wnt signalling results in transcriptional stimulation of genes controlling normal and malignant development. A key effector of the canonical Wnt pathway is beta-catenin (also known as Drosophila melanogaster Armadillo (Arm)), thought to function as a nuclear co-activator of TCF transcription factors. This has been challenged by unexpected observations of membrane-bound Arm/beta-catenin signalling activity. Plausible explanations allow these observations to be reconciled with the large body of evidence supporting a nuclear function of Arm/beta-catenin.

引用

页码：179 / 182

页数：4

共 57 条

[1] Ahmed Y, 2002, DEVELOPMENT, V129, P1751
[2] Drosophila APC2 and APC1 play overlapping roles in Wingless signaling in the embryo and imaginal discs
Akong, K
Grevengoed, EE
Price, MH
McCartney, BM
Hayden, MA
DeNofrio, JC
Peifer, M
[J]. DEVELOPMENTAL BIOLOGY, 2002, 250 (01) : 91 - 100
[3] The chromatin remodelling factor Brg-1 interacts with β-catenin to promote target gene activation
Barker, N
Hurlstone, A
Musisi, H
Miles, A
Bienz, M
Clevers, H
[J]. EMBO JOURNAL, 2001, 20 (17) : 4935 - 4943
[4] Functional interaction of beta-catenin with the transcription factor LEF-1
Behrens, J
vonKries, JP
Kuhl, M
Bruhn, L
Wedlich, D
Grosschedl, R
Birchmeier, W
[J]. NATURE, 1996, 382 (6592) : 638 - 642
[5] Belenkaya TY, 2002, DEVELOPMENT, V129, P4089
[6] TCF: transcriptional activator or repressor?
Bienz, M
[J]. CURRENT OPINION IN CELL BIOLOGY, 1998, 10 (03) : 366 - 372
[7] A beta-catenin/XTcf-3 complex binds to the siamois promoter to regulate dorsal axis specification in Xenopus
Brannon, M
Gomperts, M
Sumoy, L
Moon, RT
Kimelman, D
[J]. GENES & DEVELOPMENT, 1997, 11 (18) : 2359 - 2370
[8] pangolin encodes a Lef-1 homologue that acts downstream of Armadillo to transduce the Wingless signal in Drosophila
Brunner, E
Peter, O
Schweizer, L
Basler, K
[J]. NATURE, 1997, 385 (6619) : 829 - 833
[9] Wnt signaling: a common theme in animal development
Cadigan, KM
Nusse, R
[J]. GENES & DEVELOPMENT, 1997, 11 (24) : 3286 - 3305
[10] THE HUMAN TCF-1 GENE ENCODES A NUCLEAR DNA-BINDING PROTEIN UNIQUELY EXPRESSED IN NORMAL AND NEOPLASTIC T-LINEAGE LYMPHOCYTES
CASTROP, J
VANWICHEN, D
KOOMANSBITTER, M
VANDEWETERING, M
DEWEGER, R
VANDONGEN, J
CLEVERS, H
[J]. BLOOD, 1995, 86 (08) : 3050 - 3059

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