Angiogenic signaling in Alzheimer's disease

被引：54

作者：

Pogue, AI

Lukiw, WJ

机构：

[1] Louisiana State Univ, Hlth Sci Ctr, LSU Neurosci Ctr, New Orleans, LA 70112 USA

[2] Louisiana State Univ, Hlth Sci Ctr, Dept Ophthalmol, New Orleans, LA 70112 USA

来源：

NEUROREPORT | 2004年 / 15卷 / 09期

关键词：

Alzheimer's disease; angiogenesis; DNA array; gene expression; inflammation; VEGF;

D O I：

10.1097/01.wnr.0000130539.39937.1d

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Genome-wide expression profiling has identified significant alterations in the abundance of specific mRNA populations in Alzheimer's disease brain when compared to age-matched controls. Increases in the expression of certain brain genes are in contrast to the majority of expressed RNAs (55-67%), which are downregulated. The data presented here shows, that at the level of mRNA abundance, there is marked up-regulation in a family of stress-related genes that have significant potential to promote angiogenesis. This supports the hypothesis of an advancement in angiogenic signaling in Alzheimer's disease brain. Angiogenesis, perhaps as the result of dysfunctional cerebral vasculature, may be both a consequence and a contributory factor to the etiopathology of the Alzheimer's disease process.

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收藏

页码：1507 / 1510

页数：4

相关论文

共 25 条

[1] Prostaglandins and other lipid mediators in Alzheimer's disease [J].

Bazan, NG ;

Colangelo, V ;

Lukiw, WJ .

PROSTAGLANDINS & OTHER LIPID MEDIATORS, 2002, 68-9 :197-210

[2] Development of inflammatory angiogenesis by local stimulation of Fas in vivo [J].

Biancone, L ;

DeMartino, A ;

Orlandi, V ;

Conaldi, PG ;

Toniolo, A ;

Camussi, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1997, 186 (01) :147-152

[3] Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down-regulation and up-regulation of apoptotic and pro-inflammatory signaling [J].

Colangelo, V ;

Schurr, J ;

Ball, MJ ;

Pelaez, RP ;

Bazan, NG ;

Lukiw, WJ .

JOURNAL OF NEUROSCIENCE RESEARCH, 2002, 70 (03) :462-473

[4]

De La Torre JC, 2002, ANN NY ACAD SCI, V977, P196

[5] Chaperones increase association of tau protein with microtubules [J].

Dou, F ;

Netzer, WJ ;

Tanemura, K ;

Li, F ;

Hartl, FU ;

Takashima, A ;

Gouras, GK ;

Greengard, P ;

Xu, HX .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (02) :721-726

[6] Hypoxia and interleukin-1β stimulate vascular endothelial growth factor production in human proximal tubular cells [J].

El Awad, B ;

Kreft, B ;

Wolber, EM ;

Hellwig-Bürgel, T ;

Metzen, E ;

Fandrey, J ;

Jelkmann, W .

KIDNEY INTERNATIONAL, 2000, 58 (01) :43-50

[7] The pathological cascade of Alzheimer's disease: The role of inflammation and its therapeutic implications [J].

Hoozemans, JJM ;

Veerhuis, R ;

Rozemuller, AJM ;

Eikelenboom, P .

DRUGS OF TODAY, 2002, 38 (06) :429-443

[8] Interleukin-1β induced cyclooxygenase 2 expression and prostaglandin E2 secretion by human neuroblastoma cells:: implications for Alzheimer's disease [J].

Hoozemans, JJM ;

Veerhuis, R ;

Janssen, I ;

Rozemuller, AJM ;

Eikelenboom, P .

EXPERIMENTAL GERONTOLOGY, 2001, 36 (03) :559-570

[9]

Hromas R, 1997, BLOOD, V89, P3315

[10] Vascular endothelial growth factor in Alzheimer's disease and experimental cerebral ischemia [J].

Kalaria, RN ;

Cohen, DL ;

Premkumar, DRD ;

Nag, S ;

LaManna, JC ;

Lust, WD .

MOLECULAR BRAIN RESEARCH, 1998, 62 (01) :101-105