Neuroprotection - Challenges and opportunities

被引:99
作者
Faden, Alan I. [1 ]
Stoica, Bogdan [1 ]
机构
[1] Georgetown Univ, Dept Neurosci, Med Ctr, Washington, DC 20057 USA
关键词
D O I
10.1001/archneur.64.6.794
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
The ability of pharmacological agents to limit secondary biochemical damage and cell death has been well established in numerous animal models of stroke, head injury, and spinal cord injury, yet the results of such neuroprotective treatment strategies in human injury have been disappointing. A number of conceptual and methodological issues have undoubtedly contributed to the difficulties in translating the experimental results to the clinic. Most recently, different experimental approaches and altered clinical trial methodologies have provided renewed, albeit cautious, optimism regarding future clinical trials of neuroprotective agents. Herein, we reviewed both the critical problems and potential solutions, emphasizing recent experimental and clinical work.
引用
收藏
页码:794 / 800
页数:7
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