Oxygen in Stem Cell Biology: A Critical Component of the Stem Cell Niche

被引：1175

作者：

Mohyeldin, Ahmed ^{[1
]}

Garzon-Muvdi, Tomas ^{[1
]}

Quinones-Hinojosa, Alfredo ^{[1
]}

机构：

[1] Johns Hopkins Sch Med, Brain Tumor Stem Cell Lab, Dept Neurosurg & Oncol, Baltimore, MD 21231 USA

来源：

CELL STEM CELL | 2010年 / 7卷 / 02期

基金：

美国国家卫生研究院;

关键词：

HYPOXIA-INDUCIBLE FACTORS; MESENCHYMAL STROMAL CELLS; HUMAN BONE-MARROW; IN-VITRO; ENHANCES PROLIFERATION; STEM/PROGENITOR CELLS; SUBVENTRICULAR ZONE; DOPAMINERGIC DIFFERENTIATION; OSTEOGENIC DIFFERENTIATION; EMBRYONIC-DEVELOPMENT;

D O I：

10.1016/j.stem.2010.07.007

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

The defining hallmark of stem cells is their ability to self-renew and maintain multipotency. This capacity depends on the balance of complex signals in their microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic, mesenchymal, and neural stem cell phenotypes and also influence proliferation and cell-fate commitment. Recent evidence has identified a broader spectrum of stem cells influenced by hypoxia that includes cancer stem cells and induced pluripotent stem cells. These findings have important implications on our understanding of development, disease, and tissue-engineering practices and furthermore elucidate an added dimension of stem cell control within the niche.

引用

收藏

页码：150 / 161

页数：12

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