Psychiatric genetics: search for phenotypes

被引:248
作者
Leboyer, M
Bellivier, F
Nosten-Bertrand, M
Jouvent, R
Pauls, D
Mallet, J
机构
[1] Hop La Pitie Salpetriere, Serv Psychiat Adulte, F-75651 Paris, France
[2] Hop La Pitie Salpetriere, Lab Personnalite Conduites Adaptat, CNRS, URA 1957, F-75651 Paris, France
[3] Hop La Pitie Salpetriere, Lab Genet Neurotransmiss, CNRS, UMR C9923, F-75013 Paris, France
[4] Yale Univ, Ctr Child Study, New Haven, CT 06520 USA
关键词
D O I
10.1016/S0166-2236(97)01187-9
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Failure to obtain convincing results in psychiatric genetics can partly be attributed to the fact that progress in molecular biology and genetic epidemiology has not been followed by an equivalent development in phenotypic description. Instead of relying entirely on classical nosological approaches, we argue that identifying more homogeneous forms of diseases through a 'candidate symptom approach' among affected subjects and an endophenotype approach that identifies sub-clinical traits among non-affected relatives might yield better results. Examples where these strategies have already been fruitful when applied to complex diseases are presented in this review. Focusing on vulnerability traits might stimulate the redefinition of traditional psychiatric syndromes and help to bridge the gap between clinical and experimental approaches.
引用
收藏
页码:102 / 105
页数:4
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