Fungemia in patients with hematologic malignancies: Therapeutic effects of concomitant administration of fluconazole and granulocyte-colony-stimulating factor

被引:6
作者
Niitsu, N
Umeda, M
机构
[1] First Department of Internal Medicine, Toho University School of Medicine, Tokyo
关键词
(beta 1 -> 3)-D-glucan; fungemia; hematologic malignancy; fluconazole; granulocyte-colony-stimulating factor;
D O I
10.1159/000239445
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Serum (beta 1 --> 3)-D-glucan was elevated in 34 of 126 patients (27%) with hematologic malignancy who were clinically suspected of having a deep-seated mycosis. Although 11 patients (8.8%) were though to have fungemia, fungi were isolated from blood culture in only 4. These results suggest that measurement of serum beta-D-glucan is useful for early diagnosis. Therapy with fluconazole (FLCZ) was effective in 9 of 11 patients (81.8%) suspected of having fungemia. Fungemia responded in 5 of 7 patients who were given granulocyte-colony-stimulating factor (G-CSF) concomitantly with FLCZ. This result suggested that administration of G-CSF with FLCZ was useful therapy for fungemia, which may occur during granulocytopenia following chemotherapy with anticancer agents.
引用
收藏
页码:215 / 219
页数:5
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