Subcellular Localization of a Fluorescent Artemisinin Derivative to Endoplasmic Reticulum

被引：53

作者：

Liu, Yungen ^{[2
]}

Lok, Chun-Nam ^{[2
]}

Ko, Ben Chi-Bun ^{[2
]}

Shum, Tina Yuen-Ting ^{[2
]}

Wong, Man-Kin ^{[1
]}

Che, Chi-Ming ^{[2
]}

机构：

[1] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

[2] Univ Hong Kong, Dept Chem, Hong Kong, Hong Kong, Peoples R China

来源：

ORGANIC LETTERS | 2010年 / 12卷 / 07期

关键词：

FALCIPARUM MALARIA PARASITES; VITRO ANTIMALARIAL ACTIVITY; CENTERED FREE-RADICALS; QINGHAOSU ARTEMISININ; IN-VITRO; PLASMODIUM-FALCIPARUM; DEPENDENT ACTIVATION; CHEMICAL-REACTIVITY; BIOLOGICAL-ACTIVITY; ANTICANCER ACTIVITY;

D O I：

10.1021/ol902890j

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

A cytotoxic artemisinin derivative conjugated with a fluorescent dansyl moiety was synthesized and its subcellular localization in Hep3B cells was examined. Comparison of the localization signals of the fluorescent artemisinin derivative with organelle specific dyes revealed that endoplasmic reticulum (ER) is the main site of its accumulation.

引用

页码：1420 / 1423

页数：4

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