T-cell co-stimulatory molecules: their role in allergic immune reactions

被引：33

作者：

Kallinich, T. ^{[1
]}

Beier, K. C. ^{[1
]}

Wahn, U. ^{[1
]}

Stock, P. ^{[1
]}

Hamelmann, E. ^{[1
]}

机构：

[1] Med Univ Berlin, Charite, Dept Paediat, Div Pneumol & Immunol, Berlin, Germany

来源：

EUROPEAN RESPIRATORY JOURNAL | 2007年 / 29卷 / 06期

关键词：

allergic airway inflammation; asthma pathogenesis; co-stimulation; T-cells;

D O I：

10.1183/09031936.00094306

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The development of allergic diseases, such as allergic asthma, depends upon the initiation and maintenance of T-helper cell type-2-skewed allergen-specific immune reactions. Although it is clear that susceptibility to this process is under genetic and environmental control, the fine-tuning and regulation of the type-2 T-helper cell immune response is not yet fully understood. In this second article in the present series, current understanding regarding the involvement of T-cells and antigen-presenting cells is summarised, with emphasis on the interaction between these two types of immune regulatory cells by means of co-stimulatory molecules.

引用

页码：1246 / 1255

页数：10

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