Gastrointestinal stromal tumor, uncommitted type, with monosomies 14 and 22 as the only chromosomal abnormalities

被引：20

作者：

Marci, V ^{[1
]}

Casorzo, L ^{[1
]}

Sarotto, I ^{[1
]}

Dogliani, N ^{[1
]}

Milazzo, MG ^{[1
]}

Risio, M ^{[1
]}

机构：

[1] Osped San Lazzaro, Dept Pathol, I-12051 Alba, CN, Italy

来源：

CANCER GENETICS AND CYTOGENETICS | 1998年 / 102卷 / 02期

关键词：

D O I：

10.1016/S0165-4608(97)00319-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Karyotypic analysis of a gastric stromal tumor with the histologic and immunohistochemical features of a malignant, uncommitted lesion revealed clonal monosomies of chromosomes 14 and 22. Such changes, together with loss of chromosomes 15 and 18, as well as structural rearrangements involving chromosome 1, have been previously reported in gastrointestinal stromal tumors with smooth muscle differentiation. We suggest that monosomies of chromosomes 14 and 22 are early events in the malignant transformation of the mesenchymal cell-originating gastrointestinal stromal tumors. (C) Elsevier Science Inc., 1998.

引用

页码：135 / 138

页数：4

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