MAIL, a novel nuclear IκB protein that potentiates LPS-induced IL-6 production

被引：126

作者：

Kitamura, H ^{[1
]}

Kanehira, K

Okita, K

Morimatsu, M

Saito, M

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Biomed Sci, Biochem Lab, Sapporo, Hokkaido 0600818, Japan

[2] Iwate Univ, Fac Agr, Dept Vet Physiol, Morioka, Iwate 020, Japan

来源：

FEBS LETTERS | 2000年 / 485卷 / 01期

关键词：

lipopolysaccharide; interleukin; 6; Bcl3; I kappa B; ankyrin-repeat; inflammation;

D O I：

10.1016/S0014-5793(00)02185-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified and characterized a novel member of the ankyrin-repeat family named 'molecule possessing ankyrin-repeats induced by lipopolysaccharide' (MAIL). The C-terminal portion of MAIL shared high sequence homology,vith the I kappaB family. Intraperitoneal injection of lipopolysaccharide (LPS) into mice rapidly (< 0.5 h) induced MAIL mRNA in various tissues, particularly in the spleen, lymph node, and lung. Ectopically expressed MAIL was localized in the nucleus, and remarkably potentiated the LPS-induced mRNA expression and secretion of interleukin (IL)-6 in Swiss 3T3 cells, These findings indicate that MAIL is one of the nuclear I<kappa>B proteins and an activator of IL-6 production. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：53 / 56

页数：4

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