Rearrangements involving 12q in myeloproliferative disorders:: possible role of HMGA2 and SOCS2 genes

被引：25

作者：

Etienne, Anne

Carbuccia, Nadine

Adelaide, Jose

Bekhouche, Ismahane

Remy, Virginie

Sohn, Claudine

Sainty, Danielle

Gastaut, Jean-Albert

Olschwang, Sylviane

Birnbaum, Daniel

Mozziconacci, Marie-Joelle ^{[1
]}

Chaffanet, Max

机构：

[1] Inst J Paoli I Calmettes, INSERM, UMR599, Ctr Rech & Cancerol,Lab Oncol Mol, F-13009 Marseille, France

[2] Hop Font Pre, Serv Oncol Hematol, F-83056 Toulon, France

[3] Inst J Paoli I Calmettes, Dept Biopathol, F-13009 Marseille, France

[4] Inst J Paoli I Calmettes, Dept Clin Hematol, F-13009 Marseille, France

来源：

CANCER GENETICS AND CYTOGENETICS | 2007年 / 176卷 / 01期

关键词：

D O I：

10.1016/j.cancergencyto.2007.03.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report two cases of translocation associated with deletion on derivative chromosomes in atypical myeloproliferative disorder (MPD). In a MPD with t(3;12)(q29;q14), the rearrangement targeted the HMGA2 locus at 12q14 and deleted a region of about 1.5 megabases (Mb) at 3q29. In an MPD with t(9;12)(q13 similar to q21;q22) and JAK2 V617F mutation, array comparative genomic hybridization delineated a deletion of about 3 Mb at 9q13 similar to q21 and a deletion of about 2 Mb at 12q22 containing SOCS2. These results show that close examination of translocations in hematopoietic diseases may reveal associated microdeletions. The role of these deletions is discussed. (c) 2007 Elsevier Inc. All rights reserved.

引用

页码：80 / 88

页数：9

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