A novel microgravimetric DNA sensor with high sensitivity

被引：31

作者：

Liu, T ^{[1
]}

Tang, J

Han, MM

Jiang, L

机构：

[1] Chinese Acad Sci, Inst Chem, Ctr Mol Sci, Key Lab Colloid & Interface Sci, Beijing 100080, Peoples R China

[2] Harbin Engn Univ, Dept Chem Engn, Harbin 150001, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2003年 / 304卷 / 01期

基金：

中国国家自然科学基金;

关键词：

colloidal An; DNA sensor; quartz crystal microbalance;

D O I：

10.1016/S0006-291X(03)00531-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A novel method using an amplifier with a cantilever and gold nanoparticles successfully to extend the length of the target for the specific and high sensitive detection of DNA was reported. When the size of gold nanoparticle is 50 nm, a sensitivity of 10(-15) M for the single base mutation detection has been achieved. (C) 2003 Elsevier Science (USA). All rights reserved.

引用

收藏

页码：98 / 100

页数：3

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