An AB recombinant and its parental HIV type 1 strains in the area of the former Soviet Union: low requirements for sequence identity in recombination

被引:53
作者
Liitsola, K
Holm, K
Bobkov, A
Pokrovsky, V
Smolskaya, T
Leinikki, P
Osmanov, S
Salminen, M
机构
[1] Natl Inst Publ Hlth, HIV Lab, Dept Infect Dis Epidemiol, FIN-00300 Helsinki, Finland
[2] Russian Acad Med Sci, DI Ivanovskii Virol Inst, Moscow, Russia
[3] Russian AIDS Ctr, Moscow, Russia
[4] St Petersburg Pasteur Inst, St Petersburg, Russia
[5] UNAIDS, Joint United Nat Programme HIV AIDS, Geneva, Switzerland
关键词
D O I
10.1089/08892220050075309
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
In the former Soviet Union (SU) increasing numbers of HIV-1 infections among injecting drug users (IDU) have been reported, especially in the Ukraine. The main subtype transmitted among the IDUs seems to be subtype A, but limited numbers of subtype B cases have also been reported. In Kaliningrad, Russia, an AB recombinant strain was earlier shown to be responsible for the local outbreak. Here we describe the genetic relationship of HIV-1 strains circulating among IDUs in the former SU. For subtype A and the AB recombinant strains nearly full-length genomes were sequenced, and for one subtype B strain the entire envelope gene was cloned. The relationship between the AB recombinant strain and the subtype A and subtype B strains and the mosaic structure of the recombinant was studied by phylogenetic analysis. Ukrainian A and B strains were shown to be the probable parental viruses of the Kaliningrad AB recombinant strain. In the envelope gene the recombination breakpoint could also be precisely mapped to a region of similarity of only 14 base pairs. This suggests that only short stretches of absolute sequence identity may be needed for efficient RNA recombination between HIV-1 subtypes.
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页码:1047 / 1053
页数:7
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