Near fatal acute colchicine intoxication in a child. A case report

被引：20

作者：

Goldbart, A

Press, J

Sofer, S

Kapelushnik, J

机构：

[1] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Paediat Haematooncol Unit, Beer Sheva, Israel

[2] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Paediat Dept B, IL-84105 Beer Sheva, Israel

[3] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Paediat Rheumatol Unit, IL-84105 Beer Sheva, Israel

[4] Ben Gurion Univ Negev, Soroka Univ Med Ctr, Paediat Intens Care Unit, IL-84105 Beer Sheva, Israel

来源：

EUROPEAN JOURNAL OF PEDIATRICS | 2000年 / 159卷 / 12期

关键词：

colchicine intoxication; familial Mediterranean fever; grapefruit juice;

D O I：

10.1007/PL00008364

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

An 8-year-old child with familial Mediterranean fever exhibited signs of colchicine intoxication while receiving prophylactic doses of the drug. She developed gastrointestinal, central nervous system, cardiovascular and haematological disturbances. Over 2 months she had been drinking high doses of natural grapefruit juice which, combined with long-term colchicine therapy and a viral upper respiratory tract infection, increased her susceptibility to the drug. Conclusion To the best of our knowledge, this is the first time colchicine intoxication in this age group has been described in the English literature.

引用

页码：895 / 897

页数：3

共 15 条

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