MEIS1 and HOXA7 genes in human acute myeloid leukemia

被引：57

作者：

Afonja, O

Smith, JE

Cheng, DM

Goldenberg, AS

Amorosi, E

Shimamoto, T

Nakamura, S

Ohyashiki, K

Ohyashiki, J

Toyama, K

Takeshita, K

机构：

[1] NYU, Sch Med, Dept Pediat, New York, NY 10016 USA

[2] Metropolitan Hosp, New York Med Coll, Div Hematol Oncol, Dept Med, New York, NY USA

[3] NYU, Sch Med, Dept Environm Med, New York, NY 10016 USA

[4] NYU, Sch Med, Med & Kaplan Canc Ctr, New York, NY 10016 USA

[5] Tokyo Med Univ, Dept Med 1, Tokyo, Japan

[6] Hayashibara Biochem Labs, Fujisaki Cell Ctr, Okayama, Japan

来源：

LEUKEMIA RESEARCH | 2000年 / 24卷 / 10期

关键词：

homeobox genes; leukemogenesis; degenerate primers; bone marrow; clinical response; survival;

D O I：

10.1016/S0145-2126(00)00059-X

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Co-activation of Meisl with Hoxa7 or Hoxa9 homeobox genes by retroviral gene insertion has recently been reported to be leukemogenic in murine myeloid leukemia. In this study we determined their expression in human leukemia. Most human myeloid leukemia cell lines co-expressed MEIS1 with HOXA7 and HOXA9. Among patients with acute leukemia, 50% of AML patients expressed MEIS1, while the majority of ALL patients were negative. A total of 89.5% of patients expressing MEIS1 co-expressed HOXA7. In unadjusted models, poorer response to chemotherapy was associated with expression of HOXA7 regardless of MEIS1 status and older patients were more likely to express either gene. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：849 / 855

页数：7

共 32 条

[1] ACUTE MYELOBLASTIC-LEUKEMIA (M2) WITH TRANSLOCATION(7-11) FOLLOWED BY MARKED EOSINOPHILIA AND ADDITIONAL ABNORMALITIES OF CHROMOSOME-5
ABE, A
TANIMOTO, M
TOWATARI, M
MATSUOKA, A
KITAORI, K
KATO, H
TOYOZUMI, H
TAKEO, T
ADACHI, K
EMI, N
KAWASHIMA, K
SAITO, H
[J]. CANCER GENETICS AND CYTOGENETICS, 1995, 83 (01) : 37 - 41
[2] RETROVIRAL INSERTIONS 90 KILOBASES PROXIMAL TO THE EVI-1 MYELOID TRANSFORMING GENE ACTIVATE TRANSCRIPTION FROM THE NORMAL PROMOTER
BARTHOLOMEW, C
IHLE, JN
[J]. MOLECULAR AND CELLULAR BIOLOGY, 1991, 11 (04) : 1820 - 1828
[3] BERENDES P, 1995, LEUKEMIA, V9, P1321
[4] The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
Borrow, J
Shearman, AM
Stanton, VP
Becher, R
Collins, T
Williams, AJ
Dube, I
Katz, F
Kwong, YL
Morris, C
Ohyashiki, K
Toyama, K
Rowley, J
Housman, DE
[J]. NATURE GENETICS, 1996, 12 (02) : 159 - 167
[5] A bumper crop of cancer genes
DePinho, RA
Jacks, T
[J]. NATURE GENETICS, 1999, 23 (03) : 253 - 254
[6] Molecular classification of cancer: Class discovery and class prediction by gene expression monitoring
Golub, TR
Slonim, DK
Tamayo, P
Huard, C
Gaasenbeek, M
Mesirov, JP
Coller, H
Loh, ML
Downing, JR
Caligiuri, MA
Bloomfield, CD
Lander, ES
[J]. SCIENCE, 1999, 286 (5439) : 531 - 537
[7] Clinical, haematological and molecular studies in patients with chromosome translocation t(7;11): A study of four Chinese patients in Taiwan
Huang, SY
Tang, JL
Liang, YJ
Wang, CH
Chen, YC
Tien, HF
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1997, 96 (04) : 682 - 687
[8] t(7;11) and Trilineage myelodysplasia in acute myelomonocytic leukemia
Inaba, T
Shimazaki, C
Yoneyama, S
Hirai, H
Kikuta, T
Sumikuma, T
Sudo, Y
Yamagata, N
Ashihara, E
Goto, H
Fujita, N
Nakagawa, M
[J]. CANCER GENETICS AND CYTOGENETICS, 1996, 86 (01) : 72 - 75
[9] t(3;21)(q26;q22) with AML1 rearrangement in a de novo childhood acute monoblastic leukaemia
Johansson, B
Fioretos, T
Garwicz, S
Heim, S
Mitelman, F
[J]. BRITISH JOURNAL OF HAEMATOLOGY, 1996, 92 (02) : 429 - 431
[10] Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells
Kawagoe, H
Humphries, RK
Blair, A
Sutherland, HJ
Hogge, DE
[J]. LEUKEMIA, 1999, 13 (05) : 687 - 698

← 1 2 3 4 →