A biocatalytic route to enantioenriched, sulfanyl aldol products

被引：15

作者：

Baker-Glenn, C

Ancliff, R

Gouverneur, V

机构：

[1] Univ Oxford, Chem Res Lab, Oxford OX1 3TA, England

[2] GlaxoSmithKline, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

TETRAHEDRON | 2004年 / 60卷 / 35期

关键词：

catalytic antibodies; aldol additon; sulfur;

D O I：

10.1016/j.tet.2004.06.033

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The aldol products derived from sulfur- or selenium containing acceptors were prepared by kinetic resolution in the presence of antibody 84G3 with enantiomeric excesses ranging from 56 to 70%. Much higher level of enantioselectivity was obtained (enantiomeric excesses all superior to 96%) for sulfanyl aldol products derived from thiomethoxyacetone with three different acceptors. (C) 2004 Elsevier Ltd. All rights reserved.

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收藏

页码：7607 / 7619

页数：13

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