Death following ingestion of MDMA (ecstasy) and moclobemide

被引:70
作者
Vuori, E
Henry, JA
Ojanperä, I
Nieminen, R
Savolainen, T
Wahlsten, P
Jäntti, M
机构
[1] Univ Helsinki, Dept Forens Med, FIN-00014 Helsinki, Finland
[2] St Marys Hosp, Imperial Coll Sch Med, Acad Dept Accid & Emergency Med, London, England
[3] Univ Turku, Dept Forens Med, SF-20500 Turku, Finland
[4] Prov State Off Western Finland, Vaasa, Finland
关键词
death; interaction; Internet; MDMA; moclobemide; serotonin syndrome;
D O I
10.1046/j.1360-0443.2003.00292.x
中图分类号
R194 [卫生标准、卫生检查、医药管理];
学科分类号
摘要
Four deaths following the ingestion of moclobemide and MDMA ('ecstasy') are described. The probable cause of death in each case was serotonin syndrome as a result of an interaction between the two drugs. As none of the victims had been prescribed moclobemide it seems that each had taken the drug to enhance the effects of MDMA, with fatal consequences. Warnings are needed against misinformed attempts to potentiate the pharmacological effects of illicit drugs.
引用
收藏
页码:365 / 368
页数:4
相关论文
共 23 条
[1]   MDMA (Ecstasy) neurotoxicity: assessing and communicating the risks [J].
Boot, BP ;
McGregor, LS ;
Hall, W .
LANCET, 2000, 355 (9217) :1818-1821
[2]   Amphetamine derivative fatalities in South Australia - Is "ecstasy" the culprit? [J].
Byard, RW ;
Gilbert, J ;
James, R ;
Lokan, RJ .
AMERICAN JOURNAL OF FORENSIC MEDICINE AND PATHOLOGY, 1998, 19 (03) :261-265
[3]   EVE AND ECSTASY - A REPORT OF 5 DEATHS ASSOCIATED WITH THE USE OF MDEA AND MDMA [J].
DOWLING, GP ;
MCDONOUGH, ET ;
BOST, RO .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1987, 257 (12) :1615-1617
[4]  
*EROWID, 2000, MDMA HLTH
[5]   Fatal poisoning by MDMA (ecstasy) and MDEA: A case report [J].
Fineschi, V ;
Masti, A .
INTERNATIONAL JOURNAL OF LEGAL MEDICINE, 1996, 108 (05) :272-275
[6]   A FATAL OVERDOSE WITH 3,4-METHYLENEDIOXYAMPHETAMINE DERIVATIVES [J].
FORREST, ARW ;
GALLOWAY, JH ;
MARSH, ID ;
STRACHAN, GA ;
CLARK, JC .
FORENSIC SCIENCE INTERNATIONAL, 1994, 64 (01) :57-59
[7]   Fatal uncertainty: death-rate from use of ecstasy or heroin [J].
Gore, SM .
LANCET, 1999, 354 (9186) :1265-1266
[8]   Impaired cognitive performance in drug free users of recreational ecstasy (MDMA) [J].
Gouzoulis-Mayfrank, E ;
Daumann, J ;
Tuchtenhagen, F ;
Pelz, S ;
Becker, S ;
Kunert, HJ ;
Fimm, B ;
Sass, H .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 2000, 68 (06) :719-725
[9]  
HATTER S, 1998, PSYCHOPHARMACOLOGY, V135, P22
[10]  
*HEDWEB, 2000, RESP PAR GUID HLTH M