New insulin-mimetic zinc (II) complexes;: Bis-maltolato zinc(II) and bis-2-hydroxypyridine-N-oxide zinc(II) with Zn(O4) coordination mode

被引：70

作者：

Yoshikawa, Y

Ueda, E

Kawabe, K

Miyake, H

Sakurai, H

Kojima, Y

机构：

[1] Osaka City Univ, Grad Sch Sci, Dept Chem, Sumiyoshi Ku, Osaka 5588585, Japan

[2] Kyoto Pharmaceut Univ, Dept Analyt & Bioinorgan Chem, Yamashima Ku, Kyoto 6078414, Japan

来源：

CHEMISTRY LETTERS | 2000年 / 08期

关键词：

D O I：

10.1246/cl.2000.874

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Zinc(II) complexes with a Zn(O-4) coordination mode were found to have insulinomimetic activity. A bis-maltolato zinc(II) (Zn(Mal)(2)) complex was revealed to be in an octahedral and a square pyramidal geometries in a unit fell. Both Zn(Mal)(2) (IC50 = 0.59 mM) and bis-2-hydroxypyridine-N-oxide zinc(II) (IC50 = 0.41 mM) complexes exhibited higher insulinomimetic activity than VOSO4(IC50 = 1.00 mM) and ZnSO4(IC50 = 0.81 mM) in terms of IC50 values, which show 50% inhibition concentration of the complex in the free fatty acids release from rat adipocytes.

引用

页码：874 / 875

页数：2

共 10 条

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