The effect of activin and FSH on the differentiation of rat granulosa cells

被引：21

作者：

Kishi, H

Minegishi, T ^{[1
]}

Tano, M

Kameda, T

Ibuki, Y

Miyamoto, K

机构：

[1] Gunma Univ, Sch Med, Dept Obstet & Gynecol, Gunma 371, Japan

[2] Gunma Univ, Inst Mol & Cellular Regulat, Biosignal Res Ctr, Gunma 371, Japan

来源：

FEBS LETTERS | 1998年 / 422卷 / 02期

关键词：

activin; follicle-stimulating hormone; granulosa cell; follicle-stimulating hormone receptor; luteinizing hormone human chorionic gonadotropin receptor;

D O I：

10.1016/S0014-5793(98)00023-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The differentiation of granulosa cells is regulated by follicle-stimulating hormone (FSH) and local ovarian factors. To further analyze the role of FSH and activin in this process, we have examined the effect cl of FSH and activin on TSH and luteinizing hormone/human chorionic gonadotropin (LH/hCG) receptor induction in granulosa cells. Granulosa cells from diethylstilbestrol (DES)-primed immature rats produce activin and maintain FSH receptor without LH/hCG receptor expression in the absence iol FSH. On thr other hand, FSH induced granulosa cells to differentiate into more mature granulosa cells in which higher LH/hCG receptor expression and diminished activin production were observed. (C) 1998 Federation of European Biochemical Societies.

引用

页码：274 / 278

页数：5

共 17 条

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