Expression of tumor necrosis factor-α in regenerating muscle fibers in inflammatory and non-inflammatory myopathies

被引：81

作者：

Kuru, S ^{[1
]}

Inukai, A ^{[1
]}

Kato, T ^{[1
]}

Liang, YD ^{[1
]}

Kimura, S ^{[1
]}

Sobue, G ^{[1
]}

机构：

[1] Nagoya Univ, Grad Sch Med, Dept Neurol, Showa Ku, Nagoya, Aichi 4668550, Japan

来源：

ACTA NEUROPATHOLOGICA | 2003年 / 105卷 / 03期

关键词：

TNF-alpha; polymyositis; dermatomyositis; Duchenne muscular dystrophy; muscle regeneration;

D O I：

10.1007/s00401-002-0632-4

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The expression level of tumor necrosis factor (TNF)-alpha is elevated in idiopathic inflammatory myopathies and Duchenne muscular dystrophy (DMD), but the precise role of TNF-alpha is unknown. To elucidate the possible role of TNF-alpha, we investigated the expression of TNF-alpha and its receptor in polymyositis (PM), dermatomyositis (I)M), and DMD using in situ hybridization (ISH) and immunohistochemistry. We showed that TNF-alpha mRNA and protein were present in muscle fibers. TNF-alpha-positive fibers were observed in all cases of PM, DM and DMD, but were rare or absent in neurogenic disorders and normal controls. The proportion of TNF-alpha-positive fiber showed a significant positive correlation with the proportion of regenerating fibers that were positive for the developmental form of myosin heavy chain (MHC-d). The number of TNF receptor-positive fibers was small. Some muscle fibers expressed both TNF-alpha and its receptor simultaneously. Our results indicate that TNF-alpha is produced and expressed by muscle fibers and associated with muscle regeneration.

引用

页码：217 / 224

页数：8

共 40 条

[1] DISSOCIATION OF TNF-ALPHA CYTOTOXIC AND PROINFLAMMATORY ACTIVITIES BY P55 RECEPTOR-SELECTIVE AND P75 RECEPTOR-SELECTIVE TNF-ALPHA MUTANTS [J].

BARBARA, JAJ ;

SMITH, WB ;

GAMBLE, JR ;

VANOSTADE, X ;

VANDENABEELE, P ;

TAVERNIER, J ;

FIERS, W ;

VADAS, MA ;

LOPEZ, AF .

EMBO JOURNAL, 1994, 13 (04) :843-850

[2] THE BIOLOGY OF CACHECTIN/TNF - A PRIMARY MEDIATOR OF THE HOST RESPONSE [J].

BEUTLER, B ;

CERAMI, A .

ANNUAL REVIEW OF IMMUNOLOGY, 1989, 7 :625-655

[3] IDENTIFICATION OF 2 TYPES OF TUMOR-NECROSIS-FACTOR RECEPTORS ON HUMAN CELL-LINES BY MONOCLONAL-ANTIBODIES [J].

BROCKHAUS, M ;

SCHOENFELD, HJ ;

SCHLAEGER, EJ ;

HUNZIKER, W ;

LESSLAUER, W ;

LOETSCHER, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (08) :3127-3131

[4] EFFECT OF RECOMBINANT HUMAN-TUMOR NECROSIS FACTOR-ALPHA ON PROTEIN-SYNTHESIS IN LIVER, SKELETAL-MUSCLE AND SKIN OF RATS [J].

CHARTERS, Y ;

GRIMBLE, RF .

BIOCHEMICAL JOURNAL, 1989, 258 (02) :493-497

[5]

Davis C E, 1991, Neuromuscul Disord, V1, P411, DOI 10.1016/0960-8966(91)90004-C

[6] Immunolocalization of tumor necrosis factor-alpha and its receptors in inflammatory myopathies [J].

De Bleecker, JL ;

Meire, VI ;

Declercq, W ;

Van Aken, EH .

NEUROMUSCULAR DISORDERS, 1999, 9 (04) :239-246

[7] TUMOR-NECROSIS-FACTOR-ALPHA INCREASES THE UBIQUITINIZATION OF RAT SKELETAL-MUSCLE PROTEINS [J].

GARCIAMARTINEZ, C ;

AGELL, N ;

LLOVERA, M ;

LOPEZSORIANO, FJ ;

ARGILES, JM .

FEBS LETTERS, 1993, 323 (03) :211-214

[8]

GROUNDS MD, 1991, PATHOL RES PRACT, V187, P1

[9] Tumor necrosis factor-alpha is released from the isolated heart undergoing ischemia and reperfusion [J].

Gurevitch, J ;

Frolkis, I ;

Yuhas, Y ;

Paz, Y ;

Matsa, M ;

Mohr, R ;

Yakirevich, V .

JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 1996, 28 (01) :247-252

[10]

Inukai A, 2000, MUSCLE NERVE, V23, P385, DOI 10.1002/(SICI)1097-4598(200003)23:3<385::AID-MUS10>3.0.CO

← 1 2 3 4 →