Interrelations between hypothalamic somatostatin and proopiomelanocortin neurons

被引：18

作者：

Fodor, M

Csaba, Z

Epelbaum, J

Vaudry, H

Jegou, S

机构：

[1] U159, F-75014 Paris, France

[2] INSERM U413, Mt St Aignan, France

来源：

JOURNAL OF NEUROENDOCRINOLOGY | 1998年 / 10卷 / 02期

关键词：

somatostatin; proopiomelanocortin; immunohistochemistry; radioautography; in situ hybridization; GH control;

D O I：

10.1046/j.1365-2826.1998.00629.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Somatostatin receptors were visualized by [I-125]-Tyr0-DTrp8-somatostatin radioautography on 35% of arcuate neurons containing proopiomelanocortin (POMC) mRNA, as identified by in situ hybridization using a [S-35] labelled riboprobe on 5 mu m-thick consecutive sections, Furthermore, double immunohistochemical staining revealed contacts of beta-endorphin or alpha-MSH containing fibres with a majority of somatostatin perikarya in the anterior hypothalamic periventricular nucleus. Taken together, these data indicate that hypothalamic somatostatin and POMC neurons are interconnected, The results are discussed in term of intrahypothalamic control of GH secretion.

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页码：75 / 78

页数：4

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