Expression of CDR1, a multidrug resistance gene of Candida albicans:: Transcriptional activation by heat shock, drugs and human steroid hormones

被引：76

作者：

Krishnamurthy, S ^{[1
]}

Gupta, V ^{[1
]}

Prasad, R ^{[1
]}

Panwar, SL ^{[1
]}

Prasad, R ^{[1
]}

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, Mol Biol Lab, New Delhi 110067, India

来源：

FEMS MICROBIOLOGY LETTERS | 1998年 / 160卷 / 02期

关键词：

ABC protein; multidrug resistance; expression; stress induced; Candida albicans;

D O I：

10.1111/j.1574-6968.1998.tb12910.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We have examined the expression of CDR1 (Candida drug resistance gene) in different stress conditions. There was a significant but transient enhancement of CDR1 expression associated with elevated temperatures. Most noteworthy transcriptional activation was observed with miconazole and vinblastine. Interestingly, P-estradiol and progesterone were also able to enhance CDR1 expression. Elevated levels of CDR1 and CDR2 (a homologue of CDR1) mRNA were found in some azole-resistant clinical isolates of C. albicans. CaMDR1 (benomyl-resistant) expression, however, did not differ among all the resistant isolates. Our results confirm the existence of multiple mechanisms of azole resistance in C. albicans. (C) 1998 Federation of European Microbiological Societies. Published by Elsevier Science B.V.

引用

页码：191 / 197

页数：7

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