Renal Tubular Cyst Formation in Newborn Rats Treated with p-Cumylphenol

被引:9
作者
Nakazawa, Tomomi [1 ]
Kasahara, Kenichiro [1 ]
Ikezaki, Shinichiro [1 ]
Yamaguchi, Yuko [1 ]
Edamoto, Hiroshi [1 ]
Nishimura, Nobuo [1 ]
Yahata, Megumi [1 ]
Tamura, Kazutoshi [1 ]
Kamata, Eiichi [2 ]
Ema, Makoto [2 ]
Hasegawa, Ryuichi [2 ]
机构
[1] Bozo Res Ctr Inc, Shizuoka 4120039, Japan
[2] Natl Inst Hlth Sci, Setagaya Ku, Tokyo 1588501, Japan
关键词
p-cumylphenol; newborn rats; polycystic kidney; SIGNAL-REGULATED KINASE; KIDNEY-DISEASE; OBSTRUCTIVE NEPHROPATHY; EPITHELIAL-CELLS; PATHOPHYSIOLOGY; PROLIFERATION; ACTIVATION; APOPTOSIS;
D O I
10.1293/tox.22.125
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
In this study, we investigated the sequential changes in the development of renal tubular cysts in newborn rats treated with p-cumylphenol (PCP). Fifteen animals per sex were treated orally with 300 mg/kg/day of PCP for up to 18 days from postnatal day (PND) 4 and were sacrificed on PNDs 8, 12, 19 and 22 and after a 7 day recovery period. On PNDs 8 and 12, slight dilatation of the collecting ducts was frequently observed in the medulla and slight papillary necrosis was also noted in some cases. These dilated collecting ducts were lined with slightly hyperplastic epithelial cells. On PNDs 19 and 22, multiple large cystic changes arising from the collecting ducts in the outer medulla were seen. These cystically dilated ducts were also lined with hyperplastic epithelial cells. During the dosing period, the labeling index of proliferating cell nuclear antigen in the collecting duct epithelium was higher in the PCP-treated group than in the control group at all time points. After a 7 day recovery period, the cystic change still remained, although the cell density was decreased and the epithelial cells became flattened. On the other hand, basophilic tubules with peritubular lymphoid cell infiltration were multifocally observed in the cortex. In conclusion, PCP induced multiple renal cysts that developed in the collecting ducts of the outer medulla in neonatal rats, and it is suggested that epithelial cell proliferation may play some roles in the induction of cystic lesions. (J Toxicol Pathol 2009; 22: 125-131)
引用
收藏
页码:125 / 131
页数:7
相关论文
共 24 条
[1]  
CARONE FA, 1992, J AM SOC NEPHROL, V3, P244
[2]  
Chevalier RL, 1998, SEMIN NEPHROL, V18, P585
[3]  
Chevalier RL, 1996, J AM SOC NEPHROL, V7, P1098
[4]   Obstructive nephropathy in the neonatal rat is attenuated by epidermal growth factor [J].
Chevalier, RL ;
Goyal, S ;
Wolstenholme, JT ;
Thornhill, BA .
KIDNEY INTERNATIONAL, 1998, 54 (01) :38-47
[5]   ACQUIRED CYSTIC KIDNEY-DISEASE - THE HORMONAL HYPOTHESIS [J].
CONCOLINO, G ;
LUBRANO, C ;
OMBRES, M ;
SANTONATI, A ;
FLAMMIA, GP ;
DISILVERIO, F .
UROLOGY, 1993, 41 (02) :170-175
[6]   NEPHRON OBSTRUCTION IN NORDIHYDROGUAIARETIC ACID-INDUCED RENAL CYSTIC-DISEASE [J].
EVAN, AP ;
GARDNER, KD .
KIDNEY INTERNATIONAL, 1979, 15 (01) :7-19
[7]   Unexpected nephrotoxicity induced by tetrabromobisphenol A in newborn rats [J].
Fukuda, N ;
Ito, Y ;
Yamaguchi, M ;
Mitumori, K ;
Koizumi, M ;
Hasegawa, R ;
Kamata, E ;
Ema, M .
TOXICOLOGY LETTERS, 2004, 150 (02) :145-155
[8]   FUNCTION AND STRUCTURE IN DIPHENYLAMINE-EXPOSED KIDNEY [J].
GARDNER, KD ;
SOLOMON, S ;
FITZGERREL, WW ;
EVAN, AP .
JOURNAL OF CLINICAL INVESTIGATION, 1976, 57 (03) :796-806
[9]   RENAL CYSTIC-DISEASE INDUCED BY DIPHENYLTHIAZOLE [J].
GARDNER, KD ;
EVAN, AP .
KIDNEY INTERNATIONAL, 1983, 24 (01) :43-52
[10]   Murine models of polycystic kidney disease: molecular and therapeutic insights [J].
Guay-Woodford, LM .
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, 2003, 285 (06) :F1034-F1049