The effect of venlafaxine on behaviour, body weight and striatal monoamine levels on sleep-deprived female rats

被引:57
作者
de Oliveira, RA
Cunha, GMA
Borges, KDM
de Bruin, GS
dos Santos, EA
Viana, GSB
de Bruin, VMS
机构
[1] Fed Univ Ceara, Dept Clin Med, BR-60430140 Fortaleza, Ceara, Brazil
[2] Fed Univ Ceara, Dept Physiol & Pharmacol, BR-43027000 Fortaleza, Ceara, Brazil
关键词
sleep deprivation; venlafaxine; depression; anxiety; serotonin; dopamine; rats;
D O I
10.1016/j.pbb.2004.09.001
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
Partial sleep deprivation is clinically associated with fatigue, depressive symptoms and reduced memory. Previously, it has been demonstrated that venlafaxine, an atypical antidepressant, increases the levels of noradrenaline and serotonin in rat hippocampus. The aim of this study was to evaluate the effects of venlafaxine on depression, anxiety, locomotor activity and memory in a model of REM sleep (REMs) deprivation in rats. We have also studied the influence of venlafaxine on monoamine levels in the striatum. Six groups of animals (N=20 each) were treated with saline or venlafaxine (1 or 10 mg/kg) during 10 days, submitted or not to REMs deprivation and studied with the forced swimming test of Porsolt (STP), plus-maze, passive avoidance and open-field tests right after sleep deprivation. Animals were also studied for passive avoidance 24 h later (rebound period). Brain samples for monoamine measurements were collected either immediately after REMs deprivation or after 24 h. Both REMs deprivation and venlafaxine showed an antidepressant effect. An anxiolytic effect was also observed after REMs deprivation. Previous treatment with venlafaxine blocked the antidepressant and anxiolytic effects of REMs deprivation. REMs deprivation alone and treatment with venlafaxine 10 mg/kg increased locomotor activity, and this effect was inhibited by venlafaxine in REMs deprived rats. Both venlafaxine treatment and REMs deprivation induced weight loss. Venlafaxine treatment, but not REMs deprivation, induced an increase in striatal dopamine (DA) levels. The combination of REMs deprivation and venlafaxine treatment was associated with an increase in serotonin turnover 24 h after rebound sleep. In this study, venlafaxine treatment hindered most behavioral effects of REMs deprivation and was associated with an interference on dopamine and serotonin systems in the striatum. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:499 / 506
页数:8
相关论文
共 62 条
[1]  
AMADOBOCCARA I, 1994, ENCEPHALE, V20, P65
[2]   REM-SLEEP DEPRIVATION POTENTIATES THE EFFECTS OF IMIPRAMINE AND DESIPRAMINE BUT NOT THAT OF CLOMIPRAMINE IN THE FORCED SWIMMING TEST [J].
ASAKURA, W ;
MATSUMOTO, K ;
OHTA, H ;
WATANABE, H .
JAPANESE JOURNAL OF PHARMACOLOGY, 1993, 63 (04) :455-460
[3]  
ASAKURA W, 1994, PHARMACOL BIOCHEM BE, V48, P43
[4]   Sleep loss, a possible factor in augmenting manic episode [J].
Barbini, B ;
Bertelli, S ;
Colombo, C ;
Smeraldi, E .
PSYCHIATRY RESEARCH, 1996, 65 (02) :121-125
[5]  
BENCA RM, 1992, ARCH GEN PSYCHIAT, V49, P651
[6]   SLEEP-DEPRIVATION IN THE RAT .5. ENERGY USE AND MEDIATION [J].
BERGMANN, BM ;
EVERSON, CA ;
KUSHIDA, CA ;
FANG, VS ;
LEITCH, CA ;
SCHOELLER, DA ;
REFETOFF, S ;
RECHTSCHAFFEN, A .
SLEEP, 1989, 12 (01) :31-41
[7]  
Bonnet MH, 1998, SLEEP, V21, P477
[8]   Effects of CPAP treatment on psychological status in patients with severe obstructive sleep apnoea [J].
Borak, J ;
Cieslicki, JK ;
Koziej, M ;
Matuszewski, A ;
Zielinski, J .
JOURNAL OF SLEEP RESEARCH, 1996, 5 (02) :123-127
[9]   DETERMINANTS OF EMOTIONALITY IN THE RAT .1. SITUATIONAL FACTORS [J].
BROADHURST, PL .
BRITISH JOURNAL OF PSYCHOLOGY, 1957, 48 (01) :1-12
[10]   STRESS-RELATED BEHAVIOR AND CENTRAL NOREPINEPHRINE CONCENTRATIONS IN THE REM SLEEP-DEPRIVED RAT [J].
BROCK, JW ;
FAROOQUI, SM ;
ROSS, KD ;
PAYNE, S ;
PRASAD, C .
PHYSIOLOGY & BEHAVIOR, 1994, 55 (06) :997-1003