A clinically significant incidence of bleeding in critically ill children receiving therapeutic doses of unfractionated heparin: a prospective cohort study

被引：59

作者：

Kuhle, Stefan ^{[1
,5
]}

Eulmesekian, Pablo ^{[2
,3
]}

Kavanagh, Brian ^{[2
,3
]}

Massicotte, Patricia ^{[5
]}

Vegh, Patricia ^{[4
]}

Mitchell, Lesley G. ^{[4
,5
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Div Haematol Oncol, Dept Populat Hlth Sci, Toronto, ON, Canada

[2] Univ Toronto, Hosp Sick Children, Dept Crit Care Med, Toronto, ON, Canada

[3] Univ Toronto, Hosp Sick Children, Dept Anesthesia, Toronto, ON, Canada

[4] Univ Toronto, Hosp Sick Children, Dept Populat Hlth Sci, Toronto, ON, Canada

[5] Univ Alberta, Stollery Childrens Hosp, Dept Pediat, Edmonton, AB, Canada

来源：

HAEMATOLOGICA | 2007年 / 92卷 / 02期

基金：

奥地利科学基金会;

关键词：

unfractionated heparin; children; bleeding;

D O I：

10.3324/haematol.10616

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Unfractionated heparin (UFH) is frequently prescribed for children for the prevention and treatment of thrombosis; however, its safety and efficacy have not been assessed. The aim of this single center, prospective cohort study was to determine the incidence of major bleeding and recurrent thrombosis in children receiving UFH. Major bleeding was defined a priori as: central nervous system or retroperitoneal bleeding, bleeding resulting in UFH being stopped or overt bleeding causing a drop in hemoglobin >20 g/dL in less than 24 h. Major bleeding events occurred in 9/38 children (24%, 95% CI 11-40%) and 2/38 (5%, 95% CI 0-18%) developed thrombosis. In conclusion, there is clinically significant bleeding in children receiving UFH.

引用

页码：244 / 247

页数：4

共 11 条

[1]

ANDREW M, 1994, THROMB HAEMOSTASIS, V72, P836

[2] VENOUS THROMBOEMBOLIC COMPLICATIONS (VTE) IN CHILDREN - FIRST ANALYSES OF THE CANADIAN REGISTRY OF VTE [J].

ANDREW, M ;

DAVID, M ;

ADAMS, M ;

ALI, K ;

ANDERSON, R ;

BARNARD, D ;

BERNSTEIN, M ;

BRISSON, L ;

CAIRNEY, B ;

DESAI, D ;

GRANT, R ;

ISRAELS, S ;

JARDINE, L ;

LUKE, B ;

MASSICOTTE, P ;

SILVA, M .

BLOOD, 1994, 83 (05) :1251-1257

[3] HEPARIN CLEARANCE AND EX VIVO RECOVERY IN NEWBORN PIGLETS AND ADULT-PIGS [J].

ANDREW, M ;

OFOSU, F ;

SCHMIDT, B ;

BROOKER, L ;

HIRSH, J ;

BUCHANAN, MR .

THROMBOSIS RESEARCH, 1988, 52 (06) :517-527

[4] HEPARIN-THERAPY IN PEDIATRIC-PATIENTS - A PROSPECTIVE COHORT STUDY [J].

ANDREW, M ;

MARZINOTTO, V ;

MASSICOTTE, P ;

BLANCHETTE, V ;

GINSBERG, J ;

BRILLEDWARDS, P ;

BURROWS, P ;

BENSON, L ;

WILLIAMS, W ;

DAVID, M ;

POON, A ;

SPARLING, K .

PEDIATRIC RESEARCH, 1994, 35 (01) :78-83

[5] Low-molecular-weight heparins compared with unfractionated heparin for treatment of acute deep venous thrombosis - A meta-analysis of randomized, controlled trials [J].

Gould, MK ;

Dembitzer, AD ;

Doyle, RL ;

Hastie, TJ ;

Garber, AM .

ANNALS OF INTERNAL MEDICINE, 1999, 130 (10) :800-+

[6]

Ignjatovic V, 2006, J THROMB HAEMOST

[7] Combined thrombolytic and anticoagulant therapy for venous thrombosis in children [J].

Manco-Johnson, MJ ;

Nuss, R ;

Hays, T ;

Krupski, W ;

Drose, J ;

Manco-Johnson, ML .

JOURNAL OF PEDIATRICS, 2000, 136 (04) :446-453

[8] Increased incidence of major bleeding in children receiving unfractionated heparin for clinical management: A prospective cohort study [J].

Mitchell, LG ;

Kuhle, S ;

Massicotte, PM ;

Vegh, P .

BLOOD, 2004, 104 (11) :491A-492A

[9] Antithrombotic therapy in children [J].

Monagle, P ;

Chan, A ;

Massicotte, P ;

Chalmers, E ;

Michelson, AD .

CHEST, 2004, 126 (03) :645S-687S

[10] ANTICOAGULANT EFFECTS OF HEPARIN IN NEONATAL PLASMA [J].

SCHMIDT, B ;

OFOSU, FA ;

MITCHELL, L ;

BROOKER, LA ;

ANDREW, M .

PEDIATRIC RESEARCH, 1989, 25 (04) :405-408

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