Mapping of chemical trigger zones for reward

被引：108

作者：

Ikemoto, S ^{[1
]}

Wise, RA ^{[1
]}

机构：

[1] NIDA, Behav Neurosci Branch, NIH, Dept Hlth & Human Serv, Baltimore, MD 21224 USA

来源：

NEUROPHARMACOLOGY | 2004年 / 47卷

关键词：

nucleus accumbens; ventral tegmental area; dopamine; reinforcement; intracranial self-administration;

D O I：

10.1016/j.neuropharm.2004.07.012

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Addictive drugs are thought to activate brain circuitry that normally mediates more natural rewards such as food or water. Drugs activate this circuitry at synaptic junctions within the brain; identifying the junctions at which this occurs provides clues to the neurochemical and anatomical characteristics of the circuitry. One approach to identifying the junctions at which drugs interact with this circuitry is to determine if animals will lever-press for site-specific microinjections of addictive drugs. This approach has identified GABAergic, dopaminergic, glutamatergic, and cholinergic trigger zones within meso-corticolimbic circuitry important for natural reward function. Published by Elsevier Ltd.

引用

页码：190 / 201

页数：12

共 87 条

[1] MORPHINE ANALGESIA IN THE TAIL-FLICK AND FORMALIN PAIN TESTS IS MEDIATED BY DIFFERENT NEURAL SYSTEMS [J].

ABBOTT, FV ;

MELZACK, R ;

SAMUEL, C .

EXPERIMENTAL NEUROLOGY, 1982, 75 (03) :644-651

[2] METHOD OF DIRECT CHEMICAL BRAIN-STIMULATION IN BEHAVIORAL-STUDIES USING MICROIONTOPHORESIS [J].

AGHAJANIAN, GK ;

DAVIS, M .

PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1975, 3 (01) :127-131

[3] GABA IN THE VENTRAL TEGMENTAL AREA - DIFFERENTIAL REGIONAL EFFECTS ON LOCOMOTION, AGGRESSION AND FOOD-INTAKE AFTER MICRO-INJECTION OF GABA AGONISTS AND ANTAGONISTS [J].

ARNT, J ;

SCHEELKRUGER, J .

LIFE SCIENCES, 1979, 25 (15) :1351-1360

[4] INTRA-CRANICAL SELF-ADMINISTRATION OF MORPHINE INTO THE VENTRAL TEGMENTAL AREA IN RATS [J].

BOZARTH, MA ;

WISE, RA .

LIFE SCIENCES, 1981, 28 (05) :551-555

[5] ELECTROLYTIC MICROINFUSION TRANSDUCER SYSTEM - AN ALTERNATIVE METHOD OF INTRA-CRANICAL DRUG APPLICATION [J].

BOZARTH, MA ;

WISE, RA .

JOURNAL OF NEUROSCIENCE METHODS, 1980, 2 (03) :273-275

[6] ANATOMICALLY DISTINCT OPIATE RECEPTOR FIELDS MEDIATE REWARD AND PHYSICAL-DEPENDENCE [J].

BOZARTH, MA ;

WISE, RA .

SCIENCE, 1984, 224 (4648) :516-517

[7] OPIATE REWARDING ACTION - INDEPENDENCE OF THE CELLS OF THE LATERAL HYPOTHALAMUS [J].

BRITT, MD ;

WISE, RA .

BRAIN RESEARCH, 1981, 222 (01) :213-217

[8] AKINESIA AFTER LOCALLY APPLIED MORPHINE NEAR THE NUCLEUS RAPHE PONTIS OF THE RAT [J].

BROEKKAMP, CL ;

LEPICHON, M ;

LLOYD, KG .

NEUROSCIENCE LETTERS, 1984, 50 (1-3) :313-318

[9] SEPARATION OF INHIBITING AND STIMULATING EFFECTS OF MORPHINE ON SELF-STIMULATION BEHAVIOR BY INTRACEREBRAL MICROINJECTIONS [J].

BROEKKAMP, CL ;

VANDENBOGAARD, JH ;

HEIJNEN, HJ ;

ROPS, RH ;

COOLS, AR ;

VANROSSUM, JM .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1976, 36 (02) :443-446

[10]

CAMERON DL, 1994, J NEUROSCI, V14, P6763

← 1 2 3 4 5 6 7 8 9 →