A microcomposite hydrogel for repeated on-demand ultrasound-triggered drug delivery

被引：130

作者：

Epstein-Barash, Hila ^{[1
,2
]}

Orbey, Gizem ^{[3
]}

Polat, Bans E. ^{[2
]}

Ewoldt, Randy H. ^{[4
]}

Feshitan, Jameel ^{[5
]}

Langer, Robert ^{[2
]}

Borden, Mark A. ^{[5
]}

Kohane, Daniel S. ^{[1
]}

机构：

[1] Harvard Univ, Childrens Hosp, Sch Med, Div Crit Care Med,Dept Anesthesiol,Lab Biomat & D, Boston, MA 02115 USA

[2] MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USA

[3] Columbia Univ, Dept Biol Sci, New York, NY 10027 USA

[4] MIT, Dept Mech Engn, Cambridge, MA 01239 USA

[5] Columbia Univ, Dept Chem Engn, New York, NY 10027 USA

来源：

BIOMATERIALS | 2010年 / 31卷 / 19期

关键词：

On-demand; Triggered-release; Ultrasound; Drug delivery; Hydrogels; HYALURONIC-ACID; LIPOSOMES; RELEASE; MICROBUBBLES; ADHESIONS;

D O I：

10.1016/j.biomaterials.2010.03.008

中图分类号：

R318 [生物医学工程];

学科分类号：

100103 [病原生物学];

摘要：

Here we develop an injectable composite system based for repeated ultrasound-triggered on-demand drug delivery. An in situ-cross-linking hydrogel maintains model drug (dye)-containing liposomes in close proximity to gas-filled microbubbles that serve to enhance release events induced by ultrasound application. Dye release is tunable by varying the proportions of the liposomal and microbubble components, as well as the duration and intensity of the ultrasound pulses in vitro. Dye is minimal at baseline. The composite shows minimal cytotoxicity in vitro, and benign tissue reaction after subcutaneous injection in rats. Ultrasound application also triggers drug release for two weeks after injection in vivo. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：5208 / 5217

页数：10

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