TH17 cells in tumour immunity and immunotherapy

被引：496

作者：

Zou, Weiping ^{[1
]}

Restifo, Nicholas P. ^{[2
]}

机构：

[1] Univ Michigan, Sch Med, Dept Surg, Ann Arbor, MI 48109 USA

[2] NCI, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS IMMUNOLOGY | 2010年 / 10卷 / 04期

关键词：

REGULATORY T-CELLS; POTENT ANTITUMOR IMMUNITY; GROWTH-FACTOR-BETA; TH17; CELLS; DENDRITIC CELLS; OVARIAN-CANCER; CUTTING EDGE; AUTOIMMUNE ENCEPHALOMYELITIS; INFILTRATING LYMPHOCYTES; IL-17-PRODUCING CELLS;

D O I：

10.1038/nri2742

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T helper 17 (T(H)17) cells have well-described roles in autoimmune disease. Recent evidence suggests that this effector T cell subset is also involved in tumour immunology and may be a target for cancer therapy. In this Review, we summarize recent findings regarding the nature and relevance of T(H)17 cells in mouse models of cancer and human disease. We describe the interplay between T(H)17 cells and other immune cells in the tumour microenvironment, and we assess both the potential antitumorigenic and pro-tumorigenic activities of T(H)17 cells and their associated cytokines. Understanding the nature of T(H)17 cell responses in the tumour microenvironment will be important for the design of more efficacious cancer immunotherapies.

引用

页码：248 / 256

页数：9

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