Immunotherapy for Colorectal Cancer

被引：129

作者：

Boland, Patrick M. ^{[1
]}

Ma, Wen Wee ^{[2
]}

机构：

[1] Roswell Pk Canc Inst, Dept Med, Elm & Carlton St, Buffalo, NY 14263 USA

[2] Mayo Clin, Div Med Oncol, 200 First St SW, Rochester, MN 55905 USA

来源：

CANCERS | 2017年 / 9卷 / 05期

关键词：

colon cancer; immunotherapy; anti-PD1; MISMATCH-REPAIR DEFICIENCY; MICROSATELLITE INSTABILITY; MOLECULAR SUBTYPES; GERMLINE MUTATIONS; ANTI-PD-1; ANTIBODY; PD-1; BLOCKADE; IMMUNE; TUMOR; THERAPY; CELLS;

D O I：

10.3390/cancers9050050

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

The recent success of anti-PD1 drugs in metastatic colorectal cancer patients with mismatch repair deficiency generated overwhelming enthusiasm for immunotherapy in the disease. However, patients with mismatch repair deficient colorectal cancer represent only a small subset of the metastatic population. Current research focuses on advancing immunotherapy to earlier stages of the disease including adjuvant and first-line metastatic settings, and on inducing sensitivity to immune checkpoint inhibitor therapy through a combinatorial approach. Here, we review the contemporary understanding of the immune and molecular landscape in colorectal cancer and discuss ongoing clinical trials evaluating novel combination regimens based on immune checkpoint inhibitors.

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