Concise review: Stem cell antigen-1: Expression, function, and enigma

被引:310
作者
Holmes, Christina
Stanford, William L.
机构
[1] Univ Toronto, Inst Biomat & Biomed Engn, Toronto, ON M5S 3G9, Canada
[2] Univ Toronto, Inst Med Sci, Dept Chem Engn & Appl Chem, Toronto, ON, Canada
关键词
stem cell antigen-1; lymphocyte activation protein-6A; stem cell; self-renewal; glycosyl phosphatidylinositol-anchored protein; lipid rafts;
D O I
10.1634/stemcells.2006-0644
中图分类号
Q813 [细胞工程];
学科分类号
摘要
Cloned 20 years ago, stem cell antigen-1 (Sca-1) is used extensively to enrich for murine hematopoietic stem cells. The realization that many different stem cell types share conserved biochemical pathways has led to a flood of recent research using Sca-1 as a candidate marker in the search for tissue-resident and cancer stem cells. Although surprisingly little is still known about its biochemical function, the generation and analysis of knockout mice has begun to shed light on the functions of Sca-1 in stem and progenitor cells, demonstrating that it is more than a convenient marker for stem cell biologists. This review summarizes the plethora of recent findings utilizing Sca-1 as a parenchymal stem cell marker and detailing its functional role in stem and progenitor cells and also attempts to explain the lingering mysteries surrounding its biochemical function and human ortholog.
引用
收藏
页码:1339 / 1347
页数:9
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