CD8 T-cell memory:: the other half of the story

被引:30
作者
Masopust, D [1 ]
Lefrançois, L [1 ]
机构
[1] Univ Connecticut, Ctr Hlth, Dept Med, Div Immunol, Farmington, CT 06030 USA
关键词
infection; memory; T cell; migration; non-lymphoid;
D O I
10.1016/S1286-4579(03)00014-5
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Historically, most immune response studies have been limited to analyses of lymphoid tissue. However, peripheral sites of infection are likely to represent important sites of cell-mediated immune surveillance and effector function. Recent debates have centered on the persistence, trafficking patterns, effector activity, and protective role of non-lymphoid memory T cells. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
引用
收藏
页码:221 / 226
页数:6
相关论文
共 40 条
  • [1] Phenotypic analysis of antigen-specific T lymphocytes
    Altman, JD
    Moss, PAH
    Goulder, PJR
    Barouch, DH
    McHeyzerWilliams, MG
    Bell, JI
    McMichael, AJ
    Davis, MM
    [J]. SCIENCE, 1996, 274 (5284) : 94 - 96
  • [2] C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential
    Andrew, DP
    Ruffing, N
    Kim, CH
    Miao, WY
    Heath, H
    Li, Y
    Murphy, K
    Campbell, JJ
    Butcher, EC
    Wu, LJ
    [J]. JOURNAL OF IMMUNOLOGY, 2001, 166 (01) : 103 - 111
  • [3] Characteristics of virus-specific CD8+ T cells in the liver during the control and resolution phases of influenza pneumonia
    Belz, GT
    Altman, JD
    Doherty, PC
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (23) : 13812 - 13817
  • [4] THE CUTANEOUS LYMPHOCYTE ANTIGEN IS A SKIN LYMPHOCYTE HOMING RECEPTOR FOR THE VASCULAR LECTIN ENDOTHELIAL CELL-LEUKOCYTE ADHESION MOLECULE-1
    BERG, EL
    YOSHINO, T
    ROTT, LS
    ROBINSON, MK
    WARNOCK, RA
    KISHIMOTO, TK
    PICKER, LJ
    BUTCHER, EC
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 1991, 174 (06) : 1461 - 1466
  • [5] Lymphocyte homing and homeostasis
    Butcher, EC
    Picker, LJ
    [J]. SCIENCE, 1996, 272 (5258) : 60 - 66
  • [6] The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
    Campbell, JJ
    Haraldsen, G
    Pan, J
    Rottman, J
    Qin, S
    Ponath, P
    Andrew, DP
    Warnke, R
    Ruffing, N
    Kassam, N
    Wu, L
    Butcher, EC
    [J]. NATURE, 1999, 400 (6746) : 776 - 780
  • [7] Carlow DA, 1999, J IMMUNOL, V163, P1441
  • [8] Virus-specific CD8+ T cells in primary and secondary influenza pneumonia
    Flynn, KJ
    Belz, GT
    Altman, JD
    Ahmed, R
    Woodland, DL
    Doherty, PC
    [J]. IMMUNITY, 1998, 8 (06) : 683 - 691
  • [9] CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs
    Förster, R
    Schubel, A
    Breitfeld, D
    Kremmer, E
    Renner-Müller, I
    Wolf, E
    Lipp, M
    [J]. CELL, 1999, 99 (01) : 23 - 33
  • [10] Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation
    Goldrath, AW
    Bogatzki, LY
    Bevan, MJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (04) : 557 - 564