Arrayed micro needles for mechanical gene insertion

被引:3
作者
Cabodevila, G [1 ]
Lepioufle, B [1 ]
Fujita, H [1 ]
机构
[1] Univ Tokyo, CNRS, IIS, LIMMS,Meguro Ku, Tokyo 1538505, Japan
来源
BIOMEDICAL APPLICATIONS OF MICRO- AND NANOENGINEERING | 2002年 / 4937卷
关键词
micro needle; gene insertion; RIE etching; XeF2;
D O I
10.1117/12.473962
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
A novel approach to realize arrays of out of plane micro needles is given. The exterior shape of the micro needles is realized by dry etching using a RIE. The exterior shape is realized in silicon by dry etching using a SF6 and Argon plasma that achieve the progressive etching of the mask composed by silicon nitride and photoresist. The needles realized present an outer diameter of 900 nm for a height of about 7 microns. The needle is then realized by wet oxidation using a thin film of silicon nitride to perform a LOCOS at the end of the needle. The last step consists in selectively etch the Si3N4 and the silicon inside the needle by xenon difluoride.
引用
收藏
页码:90 / 97
页数:8
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