Use of calcined Mg-Al-hydrotalcite to enhance the stability of celecoxib in the amorphous form

The use of compound in amorphous forms is a promising approach to improve solubility of poorly water-soluble drugs. However, during storage, amorphous state can spontaneously transform to the lower energy crystalline form and this is a limiting factor for a large commercial use of drugs. In this paper, calcined hydrotalcite was employed to support amorphous celecoxib and several preparations at different weight drug/carrier ratio were prepared. Solubility of celecoxib from the prepared systems was evaluated and its physical stability during storage at different conditions was examined as well. The results show that HTIc-calc can be used as a support of amorphous celecoxib with consequent improvement of drug solubility and physical stability. (C) 2006 Elsevier B.V. All rights reserved.