Therapeutic effects of CDP-choline in Alzheimer's disease - Cognition, brain mapping, cerebrovascular hemodynamics, and immune factors

被引：68

作者：

Cacabelos, R ^{[1
]}

Caamano, J ^{[1
]}

Gomez, MJ ^{[1
]}

FernandezNovoa, L ^{[1
]}

FrancoMaside, A ^{[1
]}

Alvarez, XA ^{[1
]}

机构：

[1] UNIV COMPLUTENSE MADRID,SCH MED,DEPT HUMAN PHYSIOL,NEUROGERONTOL UNIT,MADRID,SPAIN

来源：

NEUROBIOLOGY OF ALZHEIMER'S DISEASE | 1996年 / 777卷

关键词：

D O I：

10.1111/j.1749-6632.1996.tb34452.x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

CDP-choline was given to patients with Alzheimer's disease (AD) at a daily dose of 1000 mg/day p.o. for one month. This compound slightly improved mental performance, tended to reduce theta activity in fronto-temporal regions, increasing alpha power in occipital areas, and enhanced cerebrovascular perfusion by increasing blood now velocity and reducing pulsatility and resistance indexes. In addition, CDP-choline diminished histamine and interleukin-1 levels in blood and serum, respectively, and increased plasma TNF.

引用

页码：399 / 403

页数：5

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