Triterpenoids from Pulsatilla chinensis

被引：49

作者：

Ye, WC ^{[1
]}

Ji, NN ^{[1
]}

Zhao, SX ^{[1
]}

Liu, JH ^{[1
]}

Ye, T ^{[1
]}

McKervey, MA ^{[1
]}

Stevenson, P ^{[1
]}

机构：

[1] QUEENS UNIV BELFAST,SCH CHEM,BELFAST BT9 5AG,ANTRIM,NORTH IRELAND

来源：

PHYTOCHEMISTRY | 1996年 / 42卷 / 03期

关键词：

Pulsatilla chinensis; ranunculaceae; triterpenic acid; triterpenoid glycosides; 23-hydroxybetulinic acid; pulsatillic acid; pulsatilloside A and B;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

A new lupane type triterpenic acid, pulsatillic acid, and two new lupane type triterpenoid glycosides, pulsatilloside A and B, along with the known 23-hydroxybetulinic acid were isolated from the roots of Pulsatilla chinensis. Their structures were characterized as 3-oxo-23-hydroxy-lup-20(29)-en-28-oic acid, 3 beta, 23-dihydroxy-lup-20(29)-en-28-oic acid 3-O-alpha-L-arabinopyranoside and 3 beta, 23-dihydroxy-lup-20(29)-en-28-oic acid 28-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside on the basis of hydrolysis and spectral evidence including two-dimensional relay HOHAHA, one-dimensional multiple relay COSY and ROESY NMR techniques. Pulsatillic acid exhibited cytotoxic activities against P-388, Lewis lung carcinoma and human large-cell lung carcinoma.

引用

页码：799 / 802

页数：4