DNA fingerprinting of Mycobacterium tuberculosis from patients with and without AIDS in Rio de Janeiro

被引：5

作者：

Ivens-de-Araujo, ME

Fandinho, FC

Werneck-Barreto, AM

Goncalves-Veloso, V

Grinstejn, B

Lourenco, MK

Werneck-Barroso, E

Degrave, WM

Suffys, PN

机构：

[1] FIOCRUZ, Inst Oswaldo Cruz, Dept Bioquim & Biol Mol, Lab Biol Mol & Diagnost Doencas Infecciosas, BR-21045900 Rio De Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, Dept Microbiol, Rio De Janeiro, Brazil

[3] Minist Saude, Fdn Nacl Saude, Ctr Referencia Prof Helio Fraga, Rio De Janeiro, Brazil

[4] Inst Oswaldo Cruz, Hosp Evandro Chagas, Rio De Janeiro, Brazil

来源：

BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH | 1998年 / 31卷 / 03期

关键词：

tuberculosis; fingerprinting; AIDS;

D O I：

10.1590/S0100-879X1998000300006

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Isolates of Mycobacterium tuberculosis derived from patients with AIDS from a single hospital in Rio de Janeiro were typed using a standardized RFLP technique detecting IS6110 polymorphism. Nineteen isolates were obtained from 15 different patients. Eleven distinct IS6110 patterns were found, with 4 banding patterns shared by 2 patients. The clustering value of 53% was much higher in comparison with clustering of M. tuberculosis strains from TB patients without clinical signs for HIV infection from randomly selected health centers. We present these results as preliminary data on M. tuberculosis strain polymorphism in Brazil and on the higher risk for recent transmission amongst patients with AIDS.

引用

页码：369 / 372

页数：4

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