Exceptional stereoselectivity in the synthesis of 1,3,4-trisubstituted 4-carboxy β-lactam derivatives from amino acids

被引：26

作者：

Perez-Faginas, Paula ^{[1
]}

O'Reilly, Fran ^{[1
]}

O'Byrne, Aisling ^{[1
]}

Garcia-Aparicio, Carlos ^{[1
]}

Martin-Martinez, Mercedes ^{[1
]}

de Vega, M. Jesus Perez ^{[1
]}

Garcia-Lopez, M. Teresa ^{[1
]}

Gonzalez-Muniz, Rosario ^{[1
]}

机构：

[1] CSIC, Inst Quim Med, E-28006 Madrid, Spain

来源：

ORGANIC LETTERS | 2007年 / 9卷 / 08期

关键词：

D O I：

10.1021/ol070533d

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] The base-promoted cyclization of optically pure N-(p-methoxybenzyl)-N-(2-chloro)propionyl amino acid derivatives resulted in a diastereo- and enantioselective approach to valuable 1,3,4,4-tetrasubstituted beta-lactams. The stereochemical outcome of the reaction is exclusively governed by the configuration of the N-(2-chloro)propionyl moiety.

引用

页码：1593 / 1596

页数：4

共 33 条

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