DNA degradation and protein peroxidation in cells exposed to hydroxyl free radicals

被引：12

作者：

Du, J ^{[1
]}

Gebicki, JM ^{[1
]}

机构：

[1] Macquarie Univ, Dept Sci Biol, Sydney, NSW 2109, Australia

来源：

REDOX REPORT | 2002年 / 7卷 / 05期

关键词：

D O I：

10.1179/135100002125000910

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The kinetics of DNA and protein damage in two lines of cultured cells exposed to radiation-generated hydroxyl free radicals were measured. The results show that DNA damage is a relatively late event, preceded by the formation of protein hydroperoxides which may play a role in the degradation of the DNA.

引用

页码：329 / 331

页数：3

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