Sterile inflammatory responses mediated by the NLRP3 inflammasome

被引：144

作者：

Cassel, Suzanne L. ^{[1
]}

Sutterwala, Fayyaz S. ^{[2
,3
]}

机构：

[1] Univ Iowa, Dept Internal Med, Div Allergy & Immunol, Iowa City, IA 52242 USA

[2] Univ Iowa, Dept Internal Med, Inflammat Program, Iowa City, IA 52242 USA

[3] Univ Iowa, Dept Internal Med, Div Infect Dis, Iowa City, IA 52242 USA

来源：

EUROPEAN JOURNAL OF IMMUNOLOGY | 2010年 / 40卷 / 03期

基金：

美国国家卫生研究院;

关键词：

Caspase-1; Danger signals; Necrosis; INNATE IMMUNE-RESPONSE; TOLL-LIKE RECEPTOR-4; NALP3; INFLAMMASOME; ISCHEMIA/REPERFUSION INJURY; CYTOPLASMIC DNA; CUTTING EDGE; ACTIVATION; CASPASE-1; SIGNALS; KIDNEY;

D O I：

10.1002/eji.200940207

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

Through pattern recognition receptors the innate immune system detects disruption of the normal function of the organism and initiates responses directed at correcting these derangements. Cellular damage from microbial or non-microbial insults causes the activation of nucleotide-binding domain leucine-rich repeat containing receptors in multiprotein complexes called inflammasomes. Here we discuss the role of the NLRP3 inflammasome in the recognition of cellular damage and the initiation of sterile inflammatory responses.

引用

页码：607 / 611

页数：5

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