Impurity annihilation:: Chromatography-free parallel Mitsunobu reactions

被引：67

作者：

Barrett, AGM ^{[1
]}

Roberts, RS ^{[1
]}

Schröder, J ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci Technol & Med, Dept Chem, London SW7 2AY, England

来源：

ORGANIC LETTERS | 2000年 / 2卷 / 19期

关键词：

D O I：

10.1021/ol006313g

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

GRAPHICS Mitsunobu reaction of an alcohol ROH with a carboxylic acid, phthalimide, or N-hydroxyphthalimide (NuH) using DNAD (4) and (diphenylphosphino)polystyrene (11) gave the products RNu, Ring opening metathetic polymerization of the side product DNADH(2) (3) using Cl-2(Cy3P)(2)Ru=CHPh (13) and filtration, to remove poly(DNADH(2)), (diphenylphosphino)polystyrene 11, its oxide, and its adduct with excess DNAD, gave RNu (43-100%, 88-96% purity) without recourse to chromatography.

引用

页码：2999 / 3001

页数：3

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